Cyclodextrin-based hydrogels toward improved wound dressings.

Date

2014

Advisors

Journal Title

Journal ISSN

ISSN

0738-8551
1549-7801

Volume Title

Publisher

Taylor & Francis

Type

Article

Peer reviewed

Yes

Abstract

Optimal wound dressings should be capable of mechanical wound protection and also facilitate the healing process via maintenance of suitable environmental conditions and the controlled delivery of bioactive molecules. Hydrogels present suitable properties for wound-dressing applications such as good biocompatibility, together with a high water content, the latter of which is important for the maintenance of a moist environment and ready removal from the wound with a minimal level of associated pain. However, their properties as drug delivery systems can be improved by the use of cyclodextrins as cross-linking agents. Cyclodextrins have been extensively used as “carriers” on food, textile, cosmetic and, most especially, in the pharmaceutical industry in view of their powerful complexation abilities and biocompatibilities, together with further desirable characteristics. The conjugation of cyclodextrins with hydrogels may allow the achievement of an optimal wound-dressing material, because the hydrogel component will maintain the moist environment required for the healing process, and the cyclodextrin moiety has the ability to protect and modulate the release of bioactive molecules. Therefore, this review aims to gather information regarding cyclodextrin-based hydrogels for possible wound-dressing applications.

Description

Keywords

Citation

Pinho, E. et al. (2014) Cyclodextrin-based hydrogels toward improved wound dressings. Critical Reviews in Biotechnology, 34(4), pp. 328-337.

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)