Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

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dc.cclicenceCC-BYen
dc.contributor.authorSingh, Neenuen
dc.contributor.authorNelson, Bryant C.en
dc.contributor.authorScanlan, Leona D.en
dc.contributor.authorCoskun, Erdemen
dc.contributor.authorJaruga, Pawelen
dc.contributor.authorDoak, Shareen H.en
dc.date.acceptance2017-07-04en
dc.date.accessioned2017-09-28T09:13:36Z
dc.date.available2017-09-28T09:13:36Z
dc.date.issued2017-07-13
dc.descriptionOpen Access articleen
dc.description.abstractSome engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways. This review focuses on recent studies highlighting the differential regulation of DNA repair pathways, in response to a variety of ENMs, and discusses the various factors that dictate aberrant repair processes, including intracellular signalling, spatial interactions and ENM-specific responses.en
dc.exception.reasonopen access articleen
dc.fundern/aen
dc.identifier.citationSingh, N. et al. (2017) Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways. International Journal of Molecular Sciences, 18 (7), 1515en
dc.identifier.doihttps://doi.org/10.3390/ijms18071515
dc.identifier.urihttp://hdl.handle.net/2086/14536
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidn/aen
dc.publisherMDPIen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.titleExposure to Engineered Nanomaterials: Impact on DNA Repair Pathwaysen
dc.typeArticleen

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