Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

Date

2017-07-13

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

MDPI

Type

Article

Peer reviewed

Yes

Abstract

Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways. This review focuses on recent studies highlighting the differential regulation of DNA repair pathways, in response to a variety of ENMs, and discusses the various factors that dictate aberrant repair processes, including intracellular signalling, spatial interactions and ENM-specific responses.

Description

Open Access article

Keywords

Citation

Singh, N. et al. (2017) Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways. International Journal of Molecular Sciences, 18 (7), 1515

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)