Serum albumin binding and esterase activity: mechanistic interactions with organophosphates

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dc.cclicenceCC-BYen
dc.contributor.authorGoncharov, Nikolay V.en
dc.contributor.authorBelinskaia, D. A.en
dc.contributor.authorShmurak, V. I.en
dc.contributor.authorTerpilowski, M.A.en
dc.contributor.authorJenkins, R. O.en
dc.contributor.authorAvdonin, P. V.en
dc.date.acceptance2017-07-12en
dc.date.accessioned2017-09-29T13:00:02Z
dc.date.available2017-09-29T13:00:02Z
dc.date.issued2017-07-18
dc.descriptionopen access articleen
dc.description.abstractThe albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with albumin is a special problem, and its solution could help in the development of new types of antidotes. In the present work, the history of the issue is briefly examined, then our in silico data on the interaction of human serum albumin with soman, as well as comparative in silico data of human and bovine serum albumin activities in relation to paraoxon, are presented. Information is given on the substrate specificity of albumin and we consider the possibility of its affiliation to certain classes in the nomenclature of enzymes.en
dc.exception.reasonThe output was published as gold open accessen
dc.funderRussian Science Foundation (grant 16-15-00199)en
dc.identifier.citationGoncharov, N.V. et al. (2017) Serum albumin binding and esterase activity: mechanistic interactions with organophosphates. Molecules, 22 (7), 1201en
dc.identifier.doihttps://doi.org/10.3390/molecules22071201
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/2086/14551
dc.language.isoenen
dc.peerreviewedYesen
dc.projectid16-15-00199en
dc.publisherMDPIen
dc.researchgroupBiomedical and Environmental Healthen
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.subjectalbuminen
dc.subjectesterasesen
dc.subjectorganophosphatesen
dc.subjectdockingen
dc.subjectmolecular modelingen
dc.titleSerum albumin binding and esterase activity: mechanistic interactions with organophosphatesen
dc.typeArticleen

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