Serum albumin binding and esterase activity: mechanistic interactions with organophosphates

Date

2017-07-18

Advisors

Journal Title

Journal ISSN

ISSN

1420-3049

Volume Title

Publisher

MDPI

Type

Article

Peer reviewed

Yes

Abstract

The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with albumin is a special problem, and its solution could help in the development of new types of antidotes. In the present work, the history of the issue is briefly examined, then our in silico data on the interaction of human serum albumin with soman, as well as comparative in silico data of human and bovine serum albumin activities in relation to paraoxon, are presented. Information is given on the substrate specificity of albumin and we consider the possibility of its affiliation to certain classes in the nomenclature of enzymes.

Description

open access article

Keywords

albumin, esterases, organophosphates, docking, molecular modeling

Citation

Goncharov, N.V. et al. (2017) Serum albumin binding and esterase activity: mechanistic interactions with organophosphates. Molecules, 22 (7), 1201

Rights

Research Institute

Institute for Allied Health Sciences Research