Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Date
2020-03-02
Advisors
Journal Title
Journal ISSN
ISSN
Volume Title
Publisher
American Society for Microbiology
Type
Article
Peer reviewed
Yes
Abstract
Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp. HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Description
open access article
Keywords
HT61, Staphylococcus aureus, Biofilm
Citation
Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y., Coates, A.R.M., Webb, J.S. and Allan, R.N. (2020) Antimicrobial activity of the quinolone derivative HT61 against Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy,