Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Date

2020-03-02

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

American Society for Microbiology

Type

Article

Peer reviewed

Yes

Abstract

Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp. HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Description

open access article

Keywords

HT61, Staphylococcus aureus, Biofilm

Citation

Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y., Coates, A.R.M., Webb, J.S. and Allan, R.N. (2020) Antimicrobial activity of the quinolone derivative HT61 against Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy,

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)