Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study

Date

2018-02-15

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

BMJ Publishing Group Ltd

Type

Article

Peer reviewed

Yes

Abstract

The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis, and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi colonisation, persistence of infection, and recalcitrance towards antimicrobials. There is therefore a pressing need for the development of novel treatment strategies that are effective against NTHi biofilm-associated diseases. SurgihoneyROTM is a honey-based product that has been bioengineered to enable the slow release of H2O2, a reactive oxygen species to which H. influenzae is susceptible. Treatment of established NTHi biofilms with SurgihoneyROTM significantly reduced biofilm viability through enhanced H2O2 production, and was shown to be more effective than the conventional antibiotic co-amoxiclav.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

Haemophilus influenzae, Biofilm, Reactive Oxygen

Citation

Newby, R.S., Dryden, M., Allan, R.N., et al. (2018) Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study. Journal of Clinical Pathology, 71, pp. 554-558

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)