Developing Artemisia annua for the extraction of artemisinin to treat multi-drug resistant malaria

dc.cclicenceN/Aen
dc.contributor.authorArroo, R. R. J.en
dc.contributor.authorAtkinson, C. J.en
dc.contributor.authorBentley, S.en
dc.contributor.authorBurns, C.en
dc.contributor.authorDavies, M. J.en
dc.contributor.authorDungey, N.en
dc.contributor.authorFlockhart, I.en
dc.contributor.authorHill, C.en
dc.contributor.authorRobinson, T.en
dc.contributor.authorSmith, L. M. J.en
dc.contributor.authorWoolley, J. G.en
dc.date.accessioned2016-09-29T12:54:46Z
dc.date.available2016-09-29T12:54:46Z
dc.date.issued2016-09
dc.descriptionKeynote Lecture presented at the 23rd Conference on Isoprenoids. Minsk, Belarus, September 4-7, 2016en
dc.description.abstractSemi-synthetic derivatives of the sesquiterpene artemisinin have worldwide become the main treatment for P. falciparum malaria. Artemisinin-combination therapies (ACTs), containing artemether or artesunate combined with non-isoprenoid drugs, are recommended as first line treatment by the World Health Organization, particularly in areas where resistance against quinine and quinine analogues has developed. Whereas methods for the total synthesis of artemisinin have been developed, artemisinin extracted from the leaves of Artemisia annua L. (Asteraceae) is still the preferred source for commercial production of antimalarial drugs. The biosynthetic pathway of artemisinin is well-known and a number of genes that regulate artemisinin biosynthesis have been identified. Various attempts have been made to enhance the yield of artemisinin in crops or plant cell cultures through the use of genetic engineering. Another approach has been semi-synthesis of artemisinin via artemisinic acid in genetically engineered yeast. Although genetic engineering holds a great promise for the future, currently the largest improvements in artemisinin yield have been obtained through creation of high-yielding varieties by classical breeding programs combined with modern agricultural production techniques.en
dc.funderPart of the presented work was funded by the British Department for Environment Food & Rural Affairs through the Renewable Materials LINK Programmeen
dc.identifier.citationArroo RRJ, Atkinson CJ, Bentley S, Burns C, Davies MJ, Dungey N, Flockhart I, Hill C, Robinson T, Smith LMJ, Woolley JG (2016) Developing Artemisia annua for the extraction of artemisinin to treat multi-drug resistant malaria. Весці Нацыянальнай акадэміі навук Беларусі. Серыя хімічных навук.en
dc.identifier.issn0002-3590
dc.identifier.urihttp://hdl.handle.net/2086/12658
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidLK0822en
dc.publisherNational Academy of Sciences of Belarusen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.titleDeveloping Artemisia annua for the extraction of artemisinin to treat multi-drug resistant malariaen
dc.typeConferenceen

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