The use of TDDS for investigation of structural and dynamic behavior of protein molecules in aqueous solution

Date

1998-06-20

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

Elsevier

Type

Article

Peer reviewed

Yes

Abstract

The results of the investigation of structure and dynamic behavior of protein in solution by time-domain dielectric spectroscopy are presented. The dipole correlation functions for myoglobin, lysozyme and RNase A solutions at different concentration, pH and temperature were obtained. The processes of the intramolecular interactions of myoglobin molecules, the pH-induced dimerization of lysozyme and thermal denaturation of RNase A are discussed.

Description

Keywords

Citation

Ermolina, I., Fedotov, V. and Feldman, Y. (1998) The use of TDDS for investigation of structural and dynamic behavior of protein molecules in aqueous solution. Physica A, 249 (1-4), pp. 347-352

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)