Flavonoids as Inducers of Apoptosis and Autophagy in Breast Cancer

Date

2021-06-24

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

Elsevier

Type

Book chapter

Peer reviewed

Yes

Abstract

Flavonoids are plant pigments and widely distributed in plants. They are among the most common group of polyphenolic compounds in the human diet and found in fruits, vegetables, cereals, chocolate, and beverages such as tea, coffee and wine. It is widely accepted that the dietary flavonoids in fruits and vegetables play a key role in the prevention of a range of human noncommunicable diseases including cancer, possibly by aiding eradication of aberrant cells. Apoptosis and autophagy are evolutionarily conserved processes in all eukaryotic cells. Apoptosis (Type I programmed cell death) occurs normally during development and as a homeostatic mechanism to maintain cell populations in tissues. Apoptosis also occurs as a defence mechanism under pathological conditions, when cells are damaged too severely to repair. Autophagy (Type II programmed cell death) is another cell homeostatic mechanism aimed at recycling a cell’s own nonessential macromolecular components or damaged organelles. Some flavonoids can induce apoptosis or autophagy in cancer cells via unique molecular mechanisms.

Description

Book chapter jointly written with colleagues from Haceteppe University (Ankara, Turkey) and Louisiana State University (Shreveport, LA, USA)

Keywords

Flavonoids, Cancer

Citation

Şöhretoğlu, D., Arroo, R., Sairi S, Huang, S. (2021) Flavonoids as Inducers of Apoptosis and Autophagy in Breast Cancer. In: Brahmachari, G. (Ed.) Discovery and Development of Anti-Breast Cancer Agents from Natural Products, Amsterdam: Elsevier, pp. 147-196.

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)