Developing an alternative UK industrial crop Artemisia annua, for the extraction of artemisinin to treat multi-drug resistant malaria.

Date

2010

Advisors

Journal Title

Journal ISSN

ISSN

0265-1491

DOI

Volume Title

Publisher

The Association of Applied Biologists

Type

Article

Peer reviewed

Yes

Abstract

Over the last 5 years, new Artemisia annua lines have been produced with increased artemisinin levels, where the artemisinin yield (expressed as percentage artemisinin, by weight in harvested dried leaves) increased from 1.2-2.2%. In addition to these genetic improvements, agronomic techniques that improve the overall yield of artemisinin and increase seed yield have also been achieved. Techniques for accurate measurement of artemisinin have been considered and the presence of additional compounds, which could impact on accurate measurement of the active pharmaceutical ingredient. The genetic and agronomic improvements reported here suggest that artemisinin yields in commercial production could be raised to 60 kg ha-1, a figure that compares well with the 2010 industry average of 24 kg ha-1.

Description

Keywords

Citation

Smith, L.M.J. et al. (2010) Developing an alternative UK industrial crop Artemisia annua, for the extraction of artemisinin to treat multi-drug resistant malaria. Aspects of Applied Biology 101. Non Food Uses of Crops, pp. 99-106

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)