Quantification of unimolecular photoreaction kinetics: Determination of quantum yields and development of actinometers—The photodegradation case of cardiovascular drug Nisoldipine.

dc.cclicenceCC-BYen
dc.contributor.authorMaafi, Mouniren
dc.contributor.authorMaafi, Wassilaen
dc.date.acceptance2015-05-13en
dc.date.accessioned2017-04-19T14:58:09Z
dc.date.available2017-04-19T14:58:09Z
dc.date.issued2015
dc.descriptionOpen Access articleen
dc.description.abstractThe lack of integrated rate-laws for photoreactions has led to carry out the treatment of drugs photodegradation kinetic data using the classical zeroth-, first- and second-order kinetics that were originally developed for thermal reactions. The recent developments of –order kinetic models has opened new perspectives in the treatment of photoreaction kinetics of systems involving a photolabile molecule (A) transforming into a photochemically and thermally stable product (B), i.e. the AB(1) photoreaction systems. Within this framework, the kinetics of cardiovascular and photosensitive drug Nisoldipine (NIS) has been rationalised. Continuous and monochromatic irradiation of NIS in ethanol obeyed –order kinetics with a sigmoid–shaped quantum yield variation with irradiation wavelength (0.0041–0.35 within 235–390 nm spectral region). Both NIS initial concentration-induced self photostabilisation effect and the photostabilisation by absorption competitors were quantified (up 70 %) and related to a reduction of the photokinetic factor. Finally, the –order kinetics also served to demonstrate the actinometric potential of NIS for the 320–400 nm dynamic range.en
dc.funderN/Aen
dc.identifier.citationMaafi, M. and Maafi, W. (2015) Quantification of unimolecular photoreaction kinetics: Determination of quantum yields and development of actinometers—The photodegradation case of cardiovascular drug Nisoldipine. International Journal of Photoenergy, Article ID 454895en
dc.identifier.doihttps://doi.org/10.1155/2015/454895
dc.identifier.urihttp://hdl.handle.net/2086/14071
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherHindawien
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.titleQuantification of unimolecular photoreaction kinetics: Determination of quantum yields and development of actinometers—The photodegradation case of cardiovascular drug Nisoldipine.en
dc.typeArticleen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
NIS-2015.pdf
Size:
543.44 KB
Format:
Adobe Portable Document Format
Description:
Main article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.2 KB
Format:
Item-specific license agreed upon to submission
Description: