Now showing items 1-7 of 7
MON-P095: The Effect of Fish Oil-Supplemented Gemcitabine Treatment on Leukotriene B4 Levels in Pancreatic Cancer
Pancreatic cancer (PC) is an aggressive cancer and is the 5th leading cause of cancer death in Western Europe and unfavourable prognosis is attributed to advanced disease at diagnosis and lack of effective therapy. The ...
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells
(Bentham Science Publishers, 2017-12-11)
Abstract: Background: Although the expression levels of many P450s differ between tumour and corresponding normal tissue, CYP1B1 is one of the few CYP subfamilies which is significantly and consistently overexpressed in ...
Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.
(Oxford Academic., 2017-08-18)
P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular ATP (eATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational ...
O-3 Opioids, benzodiazepines, anti-cholinergic load and clinical outcomes in patients with advanced cancer
(BMJ Publishing, 2017-03-01)
Background Medications used to manage symptoms in patients with cancer have associated, but poorly understood, harms. The aim of this study was to explore the temporal relationship between oral morphine equivalent daily ...
Factors associated with stage at diagnosis in patients with head and neck cancer
Studies have shown that diagnosis of head and neck cancer (HNC) at an advanced stage reduces the survival time compared to those diagnosed with limited disease but few have investigated the relationship of characteristics ...
Effect of Opioids and Benzodiazepines on Clinical Outcomes in Patients Receiving Palliative Care: An Exploratory Analysis
Background: Medications for symptom management in palliative care have associated, but poorly understood, harms. Drug-related harms have important clinical implications,may impact on patients’ compliance and contribute to ...