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dc.contributor.authorArroo, Randolph R.J.
dc.contributor.authorWang, Meng F
dc.contributor.authorBhambra, Avninder S.
dc.date.accessioned2020-06-02T08:53:26Z
dc.date.available2020-06-02T08:53:26Z
dc.date.issued2020-03-13
dc.identifier.citationArroo R.R.J., Wang M.F., Bhambra A.S. (2020) Chemopreventive Potential of Flavones, Flavonols, and their Glycosides. In: Xiao J., Sarker S., Asakawa Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. pp. 1-19en
dc.identifier.isbn9789811317453
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/19681
dc.descriptionCollaboration between Leicester Institute for Pharmaceutical Innovation and the Institute for Allied Heath Sciences Research.en
dc.description.abstractEpidemiological studies have long indicated a possible role for dietary flavonoids, notably flavones and flavonols, in the prevention of a range of degenerative diseases, e.g. cancer, diabetes, cardiovascular diseases and neurological disorders like Parkinson’s and Alzheimer’s disease. The flavonoids are a large and variable group of compounds, comprising thousands of different structures. The bulk of the dietary flavonoids occur as glycosides. The effect of flavonoid aglycones and their corresponding glycosides on cell metabolism and aetiology of degenerative diseases has been a topic of interest for a number of decades. In contrast, the role of the metabolic products of dietary flavonoid that reach all parts of the human body through systemic circulation, has received much less attention. Studies on animal and human metabolism have shown that the amount flavone and flavonol glycosides is absorbed intact is negligible; the bulk is absorbed only after deglycosylation. Thus, dietary glycosides are not likely to play a direct role in chemoprevention. However, the sugar groups on glycosides can greatly affect the bioavailability of flavones and flavonols. Flavonoids linked with indigestible sugars are not absorbed in the small intestine, but are transported through the digestive tract to be degraded by gut bacteria in the large intestine. The compounds that directly play a tole in the prevention of degenerative diseases are most likely not dietary flavones themselves, but rather their metabolites and conjugation products.en
dc.language.isoenen
dc.publisherSpringer Nature Switzerland AGen
dc.relation.ispartofseriesHandbook of Dietary Phytochemicals;
dc.subjectchemopreventionen
dc.subjectglucuronidesen
dc.subjectmethylated flavonesen
dc.subjectquercetinen
dc.titleChemopreventive Potential of Flavones, Flavonols, and their Glycosides.en
dc.typeBook chapteren
dc.identifier.doihttps://dx.doi.org/10.1007/978-981-13-1745-3_5-1
dc.peerreviewedYesen
dc.funderNo external funderen
dc.cclicenceN/Aen
dc.date.acceptance2020-02-08
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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