Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp. HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
open access article
Citation : Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y., Coates, A.R.M., Webb, J.S. and Allan, R.N. (2020) Antimicrobial activity of the quinolone derivative HT61 against Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy,
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes
- Leicester School of Pharmacy