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    2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

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    Accepted article - online version (743.8Kb)
    Date
    2019-11-14
    Author
    Deiva, Solene;
    Ferguson, Lindsay;
    Rateb, Mostafa;
    Williams, Roderick;
    Brucoli, Federico
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    Abstract
    We report for the first time the isolation of 2-furyl(phenyl)methanol (5) from the chloroform extracts of the Atractylis gummifera roots. A. gummifera is a thistle belonging to the Asteraceae family that produces the ent-kaurane diterpenoid glycoside atractyloside (ATR). ATR (1) was isolated and chemically modified to obtain its aglycone atractyligenin (2) and the methylated derivatives ATR-OMe (3) and genine-OMe (4). The compounds 1-5 were structurally characterised and evaluated against the intracellular amastigote, cultured within macrophages, and the extracellular promastigote of Leishmania donovani, the protozoan parasite responsible for the highly infective disease visceral leishmaniasis, which is fatal if untreated. The 2-furyl(phenyl)methanol 5 exhibited notable activity against the promastigote.
    Description
    The file attached to this record is the Publisher's final version. Crown copyright.
    Citation : Deiva, S., Ferguson, L., Rateb, M.E., Williams, R., Brucoli, F. (2019) 2-furyl (phenyl) methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity. Fitoterapia, 140, 104420.
    URI
    https://dora.dmu.ac.uk/handle/2086/18877
    DOI
    https://doi.org/10.1016/j.fitote.2019.104420
    Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
    Peer Reviewed : Yes
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    • Leicester School of Pharmacy [1196]

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