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dc.contributor.authorGoncharov, Nikolay V.
dc.contributor.authorSobolev, V. E.
dc.contributor.authorTerpilowski, M.A.
dc.contributor.authorKorf, E.A.
dc.contributor.authorJenkins, R. O.
dc.date.accessioned2019-09-26T09:17:46Z
dc.date.available2019-09-26T09:17:46Z
dc.date.issued2019-05-22
dc.identifier.citationGoncharov, N., Sobolev, V., Terpilowski, M., Korf, E. and Jenkins, R. (2019) Safety and toxicity evaluation of nutraceuticals in animal models. In: Gupta R., Srivastava A., Lall R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. pp. 675-684en
dc.identifier.isbn9783030046231
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/18520
dc.description.abstractNutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables, and fruits. Most of them possess antioxidant or anti-inflammatory properties and are claimed to provide protection against many diseases if taken regularly. At the same time, toxicological studies of nutraceuticals have been limited, so the safety of many of them cannot be guaranteed. Animals share many genetic, anatomical, and physiological similarities with humans, and they continue to be widely used in preclinical studies of drugs, in spite of a lack of their validity which is due to the great phenotypic differences. The absence of toxicity in animals provides little probability that adverse reactions will also be absent in humans. There are currently thousands of researchers involved in the development of alternatives to animal use in the life sciences. Statistical machine-learning tools, once developed, might become a powerful means to explain the complex physiological effects of nutraceuticals. The use of different models and algorithms can provide a more scientific basis for risk assessment of nutraceuticals for humans.en
dc.language.isoen_USen
dc.publisherSpringer, Chamen
dc.subjectPreclinical studiesen
dc.subjectBiomarkersen
dc.subjectSystem analysisen
dc.subjectAlternative modelsen
dc.subjectCytotoxic poweren
dc.titleSafety and toxicity evaluation of nutraceuticals in animal models.en
dc.typeBook chapteren
dc.identifier.doihttps://dx.doi.org/10.1007/978-3-030-04624-8_48
dc.peerreviewedYesen
dc.funderNo external funderen
dc.projectidN/Aen
dc.cclicenceN/Aen
dc.researchinstituteInstitute for Allied Health Sciences Researchen


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