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dc.contributor.authorEvans, S. J.en
dc.contributor.authorClifton, M. J.en
dc.contributor.authorSingh, Neenuen
dc.contributor.authorde Oliveira Mallia, J.en
dc.contributor.authorBurgum, M.en
dc.contributor.authorWills, J. W.en
dc.contributor.authorWilkinson, T. S.en
dc.contributor.authorDoak, Shareen H.en
dc.date.accessioned2018-11-08T12:07:16Z
dc.date.available2018-11-08T12:07:16Z
dc.date.issued2016-11-04
dc.identifier.citationEvans, S.J., Clift, M.J., Singh, N., de Oliveira, M.J., Burgum, M., Wills, J.W., Wilkinson, T.S., Jenkins, G.J., Doak, S.H. (2017) Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis, 32(1), pp.233-241.en
dc.identifier.urihttp://hdl.handle.net/2086/17122
dc.descriptionThe Publisher's final version can be found by following the DOI link. open access articleen
dc.description.abstractWith the need to understand the potential biological impact of the plethora of nanoparticles (NPs) being manufactured for a wide range of potential human applications, due to their inevitable human exposure, research activities in the field of NP toxicology has grown exponentially over the last decade. Whilst such increased research efforts have elucidated an increasingly significant knowledge base pertaining to the potential human health hazard posed by NPs, understanding regarding the possibility for NPs to elicit genotoxicity is limited. In vivo models are unable to adequately discriminate between the specific modes of action associated with the onset of genotoxicity. Additionally, in line with the recent European directives, there is an inherent need to move away from invasive animal testing strategies. Thus, in vitro systems are an important tool for expanding our mechanistic insight into NP genotoxicity. Yet uncertainty remains concerning their validity and specificity for this purpose due to the unique challenges presented when correlating NP behaviour in vitro and in vivo This review therefore highlights the current state of the art in advanced in vitro systems and their specific advantages and disadvantages from a NP genotoxicity testing perspective. Key indicators will be given related to how these systems might be used or improved to enhance understanding of NP genotoxicity.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subjectcoculture techniquesen
dc.subjectmutagenicity testsen
dc.subjecttoxicologyen
dc.subjectanimal testingen
dc.subjectnanoparticlesen
dc.subjectknowledge basesen
dc.titleCritical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicityen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1093/mutage/gew054
dc.peerreviewedYesen
dc.fundern/aen
dc.projectidn/aen
dc.cclicenceCC BYen
dc.date.acceptance2016en
dc.exception.reasonThe output was published as gold open accessen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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