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dc.contributor.authorDoak, Shareen H.en
dc.contributor.authorWills, J. W.en
dc.contributor.authorSingh, Neenuen
dc.date.accessioned2018-11-07T16:27:13Z
dc.date.available2018-11-07T16:27:13Z
dc.date.issued2017-11-13
dc.identifier.citationSingh, N., Wills, J.W. and Doak, S.H. (2017) Three-dimensional Models for In vitro Nanotoxicity Testing. In: Alok Dhawan, Diana Anderson, Rishi Shanker, eds. Nanotoxicology: Experimental and Computational Perspectives, Cambridge, UK, pp. 248 – 275en
dc.identifier.isbn9781782621584
dc.identifier.urihttp://hdl.handle.net/2086/17108
dc.description.abstractThe intrinsic limitations and pitfalls exhibited by two-dimensional (2D) in vitro studies in conjunction with the ethical issues surrounding in vivo (nano)toxicology testing on animals have prompted the need to develop three-dimensional (3D) models. This chapter discusses the problems faced when using monolayer cell cultures for safety assessment, which led to the rationale behind the development of 3D models for safety evaluation purposes. The additional benefits of 3D models for nanosafety are presented, coupled with an overview of some of the 3D in vitro models that have been developed to mimic the physiological environment of certain tissues/organs including liver, lung, colon, intestine and gastrointestinal tract.en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.subjectnanomedicineen
dc.subjectnanotoxicologyen
dc.subject3D modelsen
dc.titleThree-dimensional Models for In vitro Nanotoxicity Testingen
dc.typeBook chapteren
dc.identifier.doihttps://doi.org/10.1039/9781782623922-00248
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidn/aen
dc.cclicenceN/Aen
dc.date.acceptance2018-01-31en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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