Elastic Anti-Bacterial Membranes Comprising Particulate Laden Fibers for Wound Healing Applications
Medicated skin care products are available in various forms; ranging from lotions and creams to bandages and membranes. In this study, anti-bacterial particulate laden fibrous membranes were prepared via electrospraying of tetracycline hydrochloride (TE-HCL) loaded poly(ε-caprolactone) (PCL) particles alongside electrospinning of thermoplastic polyurethane (TPU) fibers, through which both mechanical and biological aspects of a complete membrane system can be achieved. Random (R) and ordered (P and V) patterns of TPU fibrous membranes (FMs) were afforded using a rotating collector. Water contact angle and bacterial inhibition zone tests were performed to assess suitability of the system specifically for wound care. Stress-strain and in-vitro drug release tests were performed to assess suitability of newly developed systems specifically for hybrid membranes (HMs). The highest tensile strength (32.1 ± 4.9 MPa) with elasticity (104.2 ± 6.0 %) and the most sustained release rate indicate HMs (P) are potentially suitable materials for wound care applications.
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Citation : Lia, Y. et al. (2018) Elastic Anti-Bacterial Membranes Comprising Particulate Laden Fibers for Wound Healing Applications. Applied Polymer Science, 136 (8), 47105
Research Group : Pharmaceutical Technologies
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes
- Leicester School of Pharmacy