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dc.contributor.authorNadeev, A.D.en
dc.contributor.authorTerpilowski, M.A.en
dc.contributor.authorBogdanov, V.A.en
dc.contributor.authorKhmelevskoy, D.A.en
dc.contributor.authorSchegolev, B.F.en
dc.contributor.authorSurma, S.V.en
dc.contributor.authorStefanov, V.E.en
dc.contributor.authorGoncharov, Nikolay V.en
dc.contributor.authorJenkins, R. O.en
dc.date.accessioned2018-08-22T12:56:40Z
dc.date.available2018-08-22T12:56:40Z
dc.date.issued2018-06-19
dc.identifier.citationNadeev, A.D. et al. (2018) Effects of exposure of rat erythrocytes to a hypogeomagnetic field. Biomedical Spectroscopy and Imaging, 7 (3-4), pp. 105-113en
dc.identifier.issn2212-8794
dc.identifier.urihttp://hdl.handle.net/2086/16501
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractBackground:Hypomagnetic fields can disrupts the normal functioning of living organisms by a mechanism thought to involve oxidative stress. In erythrocytes, oxidative stress can inter alia lead to changes to hemoglobin content and to hemolysis. Objective:To study the effects of hypomagnetism on the state of rat erythrocytes in vitro. Methods:Rat erythrocytes were exposed to an attenuated magnetic field (AMF) or Earth’s magnetic field (EMF), in the presence of tert-butyl hydroperoxide (TBHP) as inducer of oxidative stress. Determinations: total hemoglobin (and its three forms – oxyhemoglobin, methemoglobin, and hemichrome) released from erythrocytes, spectral data (500–700 nm); oxygen radical concentrations, electron paramagnetic resonance. Results:AMF and EMF exposed erythrocytes were compared. After 4 h incubation at high TBHP concentrations (>700 μM), AMF exposed erythrocytes released significantly more (p<0.05) hemoglobin (Hb), mostly as methemoglobin (metHb). Conversely, after 24 h incubation at low TBHP concentrations (⩽350 μM), EMF exposed erythrocytes released significantly more (p<0.001) hemoglobin, with metHb as a significant proportion of the total Hb. Erythrocytes exposed to AMF generated more radicals than those exposed to the EMF. Conclusion:Under particular conditions of oxidative stress, hypomagnetic fields can disrupt the functional state of erythrocytes and promote cell death; an additive effect is implicated.en
dc.publisherIOS Pressen
dc.relation.ispartofseriesBiomedical Spectroscopy and Imaging;
dc.subjectErythrocytesen
dc.subjecthaemoglobinen
dc.subjecthypomagnetic fielden
dc.subjectreactive oxygen speciesen
dc.subjectcell deathen
dc.titleEffects of exposure of rat erythrocytes to a hypogeomagnetic fielden
dc.typeArticleen
dc.identifier.doihttps://dx.doi.org/10.3233/BSI-180181
dc.researchgroupInstitute of Allied Health Sciences Researchen
dc.peerreviewedYesen
dc.explorer.multimediaNoen
dc.funderRussian FASO (programme АААА-А18-118012290142-9); Program of Fundamental Scientific Investigations of State Academies for 2014-2020 (SP-14, division 63)en
dc.projectidRussian FASO (programme АААА-А18-118012290142-9); Program of Fundamental Scientific Investigations of State Academies for 2014-2020 (SP-14, division 63)en
dc.cclicenceCC-BY-NDen
dc.date.acceptance2018-06-02en
dc.researchinstituteInstitute for Allied Health Sciences Researchen


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