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    Effects of exposure of rat erythrocytes to a hypogeomagnetic field

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    Date
    2018-06-19
    Author
    Nadeev, A.D.;
    Terpilowski, M.A.;
    Bogdanov, V.A.;
    Khmelevskoy, D.A.;
    Schegolev, B.F.;
    Surma, S.V.;
    Stefanov, V.E.;
    Goncharov, Nikolay V.;
    Jenkins, R. O.
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    Abstract
    Background:Hypomagnetic fields can disrupts the normal functioning of living organisms by a mechanism thought to involve oxidative stress. In erythrocytes, oxidative stress can inter alia lead to changes to hemoglobin content and to hemolysis. Objective:To study the effects of hypomagnetism on the state of rat erythrocytes in vitro. Methods:Rat erythrocytes were exposed to an attenuated magnetic field (AMF) or Earth’s magnetic field (EMF), in the presence of tert-butyl hydroperoxide (TBHP) as inducer of oxidative stress. Determinations: total hemoglobin (and its three forms – oxyhemoglobin, methemoglobin, and hemichrome) released from erythrocytes, spectral data (500–700 nm); oxygen radical concentrations, electron paramagnetic resonance. Results:AMF and EMF exposed erythrocytes were compared. After 4 h incubation at high TBHP concentrations (>700 μM), AMF exposed erythrocytes released significantly more (p<0.05) hemoglobin (Hb), mostly as methemoglobin (metHb). Conversely, after 24 h incubation at low TBHP concentrations (⩽350 μM), EMF exposed erythrocytes released significantly more (p<0.001) hemoglobin, with metHb as a significant proportion of the total Hb. Erythrocytes exposed to AMF generated more radicals than those exposed to the EMF. Conclusion:Under particular conditions of oxidative stress, hypomagnetic fields can disrupt the functional state of erythrocytes and promote cell death; an additive effect is implicated.
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    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
    Citation : Nadeev, A.D. et al. (2018) Effects of exposure of rat erythrocytes to a hypogeomagnetic field. Biomedical Spectroscopy and Imaging, 7 (3-4), pp. 105-113
    URI
    http://hdl.handle.net/2086/16501
    DOI
    https://dx.doi.org/10.3233/BSI-180181
    ISSN : 2212-8794
    Research Group : Institute of Allied Health Sciences Research
    Research Institute : Institute for Allied Health Sciences Research
    Peer Reviewed : Yes
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