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dc.contributor.authorArroo, R. R. J.en
dc.contributor.authorHano, C.en
dc.contributor.authorRenouard, S.en
dc.contributor.authorCorbin, C.en
dc.contributor.authorDrouet, S.en
dc.contributor.authorMedvedec, B.en
dc.contributor.authorDoussot, J.en
dc.contributor.authorColas, C.en
dc.contributor.authorMaunit, B.en
dc.contributor.authorBhambra, Avninder S.en
dc.contributor.authorGontier, E.en
dc.contributor.authorJullian, N.en
dc.contributor.authorMesnard, F.en
dc.contributor.authorBoitel, M.en
dc.contributor.authorAbbasi, B. H.en
dc.contributor.authorLainé, E.en
dc.date.accessioned2018-05-09T14:53:00Z
dc.date.available2018-05-09T14:53:00Z
dc.date.issued2018-03-26
dc.identifier.citationRenouard, S., Corbin, C., Drouet, S., Medvedec, B., Doussot, J., Colas, C., Maunit, B., Bhambra, A.S., Gontier, E., Jullian, N., Mesnard, F., Boitel, M., Abbasi, B.H., Arroo, R.R.J., Lainé, E., Hano, C. (2018) Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans. International Journal of Molecular Science. 19 (4), E990en
dc.identifier.urihttp://hdl.handle.net/2086/16157
dc.descriptionCollaboration with: Université d’Orléans, 28000 Chartres, France, Université de Picardie Jules Verne, F-80037 Amiens, France De Montfort University Open access articleen
dc.description.abstractLinum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC 15834. Both strains were effective for transformation but induction of hairy root phenotype was more stable with strain ATCC 15834. Whereas similar accumulation patterns were observed in podophyllotoxin-related compounds (6-methoxy-podophyllotoxin, podophyllotoxin and deoxypodophyllotoxin), significant quantitative variations were noted between root lines. The influence of culture medium and various treatments (hormone, elicitation and precursor feeding) were evaluated. The highest accumulation was obtained in Gamborg B5 medium. Treatment with methyl jasmonate, and feeding using ferulic acid increased the accumulation of aryltetralin lignans. These results point to the use of hairy root culture lines of Linum flavum as potential sources for these valuable metabolites as an alternative, or as a complement to Podophyllum collected from wild stands.en
dc.language.isoenen
dc.publisherMDPIen
dc.subjectaryltetralin lignansen
dc.subjectdeoxypodophyllotoxinen
dc.subject6-Methoxy-podophyllotoxinen
dc.subjectPodophyllotoxinen
dc.subjecthairy rooten
dc.subjectLinum flavumen
dc.titleInvestigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans.en
dc.typeArticleen
dc.identifier.doihttps://dx.doi.org/10.3390/ijms19040990
dc.researchgroupNatural Products Researchen
dc.peerreviewedYesen
dc.fundern/aen
dc.projectidn/aen
dc.cclicenceCC BYen
dc.date.acceptance2018-03-26en
dc.exception.reasonThe output was published as gold open accessen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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