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    Resting state fMRI entropy probes complexity of brain activity in adults with ADHD

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    Date
    2013-10-15
    Author
    Sokunbi, M.O.;
    Fung, W.;
    Sawlani, V.;
    Choppin, S.;
    Linden, D.E.J.;
    Thome, J.
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    Abstract
    In patients with attention deficit hyperactivity disorder (ADHD), quantitative neuroimaging techniques have revealed abnormalities in various brain regions, including the frontal cortex, striatum, cerebellum, and occipital cortex. Nonlinear signal processing techniques such as sample entropy have been used to probe the regularity of brain magnetoencephalography signals in patients with ADHD. In the present study, we extend this technique to analyse the complex output patterns of the 4 dimensional resting state functional magnetic resonance imaging signals in adult patients with ADHD. After adjusting for the effect of age, we found whole brain entropy differences (P=0.002) between groups and negative correlation (r=-0.45) between symptom scores and mean whole brain entropy values, indicating lower complexity in patients. In the regional analysis, patients showed reduced entropy in frontal and occipital regions bilaterally and a significant negative correlation between the symptom scores and the entropy maps at a family-wise error corrected cluster level of P<0.05 (P=0.001, initial threshold). Our findings support the hypothesis of abnormal frontal-striatal-cerebellar circuits in ADHD and the suggestion that sample entropy is a useful tool in revealing abnormalities in the brain dynamics of patients with psychiatric disorders.
    Description
    Citation : Sokunbi, M.O., Fung, W., Sawlani, V., Choppin, S., Linden, D.E.J., Thome, J. (2013) Resting state fMRI entropy probes complexity of brain activity in adults with ADHD. Psychiatry Research: Neuroimaging, 24(3), pp.341-348.
    URI
    http://hdl.handle.net/2086/15472
    DOI
    https://doi.org/10.1016/j.pscychresns.2013.10.001
    ISSN : 0925-4927
    Research Institute : Institute for Allied Health Sciences Research
    Peer Reviewed : Yes
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    • School of Allied Health Sciences [1415]

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