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dc.contributor.authorMatsuura, H.N.en
dc.contributor.authorMalik, S.en
dc.contributor.authorde Costa, F.en
dc.contributor.authorYousefzadi, M.en
dc.contributor.authorMirjalili, M. H.en
dc.contributor.authorArroo, R. R. J.en
dc.contributor.authorBhambra, Avninder S.en
dc.contributor.authorStrnad, M.en
dc.contributor.authorBonfill, M.en
dc.contributor.authorFett-Neto, A.G.en
dc.date.accessioned2018-01-18T12:14:46Z
dc.date.available2018-01-18T12:14:46Z
dc.date.issued2017-12-30
dc.identifier.citationMatsuura H.L., Malik S., de Costa F., Yousefzadi M., Mirjalili M.H., Arroo R., Bhambra A.S., Strnad M., Bonfill M., Fett-Neto A.G. (2017) Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production. Molecular Biotechnology, pp.1-15en
dc.identifier.issn1559-0305
dc.identifier.issn1073-6085
dc.identifier.urihttp://hdl.handle.net/2086/15083
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linken
dc.description.abstractPlant secondary metabolism evolved in the context of highly organized and differentiated cells and tissues, featuring massive chemical complexity operating under tight environmental, developmental and genetic control. Biotechnological demand for natural products has been continuously increasing because of their significant value and new applications, mainly as pharmaceuticals. Aseptic production systems of plant secondary metabolites have improved considerably, constituting an attractive tool for increased, stable and large-scale supply of valuable molecules. Surprisingly, to date, only a few examples including taxol, shikonin, berberine and artemisinin have emerged as success cases of commercial production using this strategy. The present review focuses on the main characteristics of plant specialized metabolism and their implications for current strategies used to produce secondary compounds in axenic cultivation systems. The search for consonance between plant secondary metabolism unique features and various in vitro culture systems, including cell, tissue, organ, and engineered cultures, as well as heterologous expression in microbial platforms, is discussed. Data to date strongly suggest that attaining full potential of these biotechnology production strategies requires being able to take advantage of plant specialized metabolism singularities for improved target molecule yields and for bypassing inherent difficulties in its rational manipulation.en
dc.language.isoen_USen
dc.publisherSpringeren
dc.subjectGenetically engineered culturesen
dc.subjectIn vitro cultureen
dc.subjectNatural Productsen
dc.subjectSecondary Metabolitesen
dc.subjectSynthetic biologyen
dc.titleSpecialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production.en
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1007/s12033-017-0056-1
dc.peerreviewedYesen
dc.funderConselho Nacional de Desenvolvimento Científico e Tecnológicoen
dc.funderFundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhãoen
dc.projectid306079/2013-5en
dc.projectid2016en
dc.cclicenceCC-BY-NCen
dc.date.acceptance2017-12-30en
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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