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dc.contributor.authorOwen, Lucyen
dc.contributor.authorLaird, Katieen
dc.date.accessioned2018-01-11T13:19:32Z
dc.date.available2018-01-11T13:19:32Z
dc.date.issued2018-01-10
dc.identifier.citationOwen, L. and Laird, K. (2018) Synchronous application of antibiotics and essential oils: dual mechanisms of action as a potential solution to antibiotic resistance, Critical Reviews in Microbiology, 44 (4), pp. 414-435en
dc.identifier.issn1040-841X
dc.identifier.issn1549-7828
dc.identifier.urihttp://hdl.handle.net/2086/15068
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linken
dc.description.abstractAntibiotic resistance has increased dramatically in recent years, yet the antibiotic pipeline has stalled. New therapies are therefore needed to continue treating antibiotic resistant infections. One potential strategy currently being explored is the use of non-antibiotic compounds to potentiate the activity of currently-employed antibiotics. Many natural products including Essential Oils (EOs) possess broad spectrum antibacterial activity and so have been investigated for this purpose. This article aims to review recent literature concerning the antibacterial activity of EOs and their interactions with antibiotics, with consideration of dual mechanisms of action of EOs and antibiotics as a potential solution to antibiotic resistance. Synergistic interactions between EOs and their components with antibiotics have been reported, including several instances of antibiotic resensitization in resistant isolates, in support of this strategy to control antibiotic resistance. However, a lack of consistency in methods and interpretation criteria makes drawing conclusions of efficacy of studied combinations difficult. Synergistic effects are often not explored beyond preliminary identification of antibacterial interactions and mechanism of action is rarely defined, despite many hypotheses and recommendations for future study. Much work is needed to fully understand EO-antibiotic associations before they can be further developed into novel antibacterial formulations.en
dc.language.isoenen
dc.publisherTaylor and Francisen
dc.subjectantibiotic resistanceen
dc.subjectessential oilen
dc.subjectantibacterial interactionsen
dc.subjectsynergyen
dc.subjectmechanism of actionen
dc.titleSynchronous application of antibiotics and essential oils: dual mechanisms of action as a potential solution to antibiotic resistanceen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1080/1040841X.2018.1423616
dc.researchgroupInfectious Disease Research Groupen
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.date.acceptance2018-01-01en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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