Purinergic receptors in skeletal muscles in health and in muscular dystrophy
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways. Members of both groups have been identified in skeletal muscle cells at different stages of differentiation. It is well documented that sequential expression and down-regulation of particular P2 receptors on the surface of sarcolemma is closely associated with muscle maturation during embryogenesis and postnatal growth. P2 receptors are also involved in muscle regeneration following injury. Moreover, enhanced expression of specific purinergic receptors together with increased availability of extracellular ATP in dystrophic muscles are important elements of the dystrophic pathophysiology considerably increasing severity.
Citation : Krasowska, E., Rog, J., Sinadinos, A., Young, CNJ., Gorecki, D., Zablocki, K. (2014). Purinergic receptors in skeletal muscles in health and in muscular dystrophy. Postępy Biochemii, 60(4), pp.483-489.
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes