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dc.contributor.authorAlshareef, A.en
dc.contributor.authorLaird, Katieen
dc.contributor.authorCross, R. B. M.en
dc.date.accessioned2017-03-22T11:20:30Z
dc.date.available2017-03-22T11:20:30Z
dc.date.issued2017-03-23
dc.identifier.citationAlshareef, A., Laird, K. and Cross, R. (2017) Shape-dependent antibacterial activity of silver nanoparticles on Escherichia.coli and Enterococcus.faecium bacterium. Applied Surface Science, 424 (3), pp. 310-315en
dc.identifier.urihttp://hdl.handle.net/2086/13815
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractSilver nanoparticles (AgNPs) have been shown to exhibit strong antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria including antibiotic resistant strains. The antibacterial activity of AgNPs against Escherichia coli and Streptococcus mutans (S. Mutans) has been reported and found to be size dependent. This study aims to compare the bactericidal effect of different shaped AgNPs (spherical and truncated octahedral) against E.coli and E.faecium. The antimicrobial activity of a range of concentrations (50, 100, 1000μg/ml) was determined over 24 hours using both optical density and viable counts. Truncated octahedral AgNPs (AgNoct) were found to be more active when compared with spherical AgNPs (AgNS). The difference in shape resulted in differences in efficacy which may be due to the higher surface area of AgNOct compared to AgNS, and differences in active facets and surface energies, with AgNPs having a bacteriostatic effect and AgNOct is being bactericidal after 4 hours. The results suggest that AgNPs can be used as effective growth inhibitors in different microorganisms, rendering them applicable tovarious medical devices and antimicrobial control systems.en
dc.publisherElsevieren
dc.subjectAgNPsen
dc.subjectshape-dependenten
dc.subjectantibacterial activityen
dc.subjectE.colien
dc.subjectEnterococcus spen
dc.titleShape-dependent antibacterial activity of silver nanoparticles on Escherichia.coli and Enterococcus.faecium bacteriumen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.apsusc.2017.03.176
dc.researchgroupEmerging Technologies Research Centreen
dc.researchgroupInfectious Disease Research Group
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2017-03-20en
dc.researchinstituteInstitute of Engineering Sciences (IES)en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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