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dc.contributor.authorLaird, Katieen
dc.contributor.authorOwen, Lucyen
dc.contributor.authorRuiz-Rodado, Victoren
dc.contributor.authorPrice, Pennyen
dc.contributor.authorGrootveld, M.en
dc.contributor.authorArroo, R. R. J.en
dc.date.accessioned2017-01-09T16:39:39Z
dc.date.available2017-01-09T16:39:39Z
dc.date.issued2017-01-26
dc.identifier.citationOwen, L., Grootveld, M., Arroo, R., Ruiz-Rodado, V., Price, P. and Laird, K. (2017) A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria. Phytotherapy Research, 31 (3), pp. 410-417en
dc.identifier.urihttp://hdl.handle.net/2086/13150
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractAcne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating Essential Oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Antimicrobial screening of rosewood, clove bud and litsea EOs was conducted and interactions between binary and ternary combinations determined against P. acnes and S. epidermidis (type and clinical isolates) using Minimum Inhibitory Concentrations (MICs) and Fractional Inhibitory Concentrations (FICs). The EOs were characterised by both GC-MS and NMR. A combination of 0.53 mg/ml litsea, 0.11 mg/ml rosewood and 0.11 mg/ml clove bud were formulated into herbal distillates and compared to Dalacin T and Stiemycin against antibiotic sensitive and resistant isolates (erythromycin). The distillate with EO had synergistic activity against P. acnes (7log10 reduction) and indifferent activity against S. epidermidis, (6log10 reduction), antimicrobial activity was either significantly (p ≤ 0.05) more antimicrobial or equivalent to that of Dalacin T and Stiemycin. This formulation may serve as a valuable alternative for the control of acne vulgaris-associated bacteria.en
dc.language.isoenen
dc.subjectEssential oilsen
dc.subjectacne vulgarisen
dc.subjectPropionibacterium acnesen
dc.subjectStaphylococcus epidermidisen
dc.subjectantimicrobial synergyen
dc.titleA Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria.en
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1002/ptr.5762
dc.researchgroupInfectious Disease Research Group
dc.peerreviewedYesen
dc.funderPartnership in Knowledge Transferen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2016-11-30en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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