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    Browsing Leicester School of Pharmacy by Subject "activation"

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      • Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K 

        Cheng, Z.; Surichan, Somchaiya; Ruparelia, K. C.; Arroo, R. R. J.; Boarder, M. R. (Article)
        The mechanisms by which the dietary compound tangeretin has anticancer effects may include acting as a prodrug, forming an antiproliferative product in cancer cells. Here we show that tangeretin also inhibits cell cycle ...

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