Browsing Leicester School of Pharmacy by Subject "P450"

Now showing items 1-2 of 2

Biphenyl urea derivatives as selective CYP1B1 inhibitors

Siddique, Mohd Usman Mohd; Sonawane, Vinay; Horley, Neill; Williams, Ibidapo Steven; Joshi, Prashant; Bharate, Sandip B.; Jayaprakash,Venkatesan; Sinha, Barij N.; Chaudhuri, Bhabatosh; McCann, Glen J. P. (Article)

Highly selective CYP1B1 inhibitors have potential in the treatment of hormone-induced breast and prostate cancers. Mimicry of potent and selective CYP1B1 inhibitors, α-naphthoflavone and stilbenes, revealed that two ...
Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells.

Joshi, Prashant; McCann, Glen J. P.; Sonawane, V. R.; Vishwakarma, R. A.; Chaudhuri, B.; Bharate, S. B. (Article)

Target structure-guided virtual screening (VS) is a versatile, powerful, and inexpensive alternative to experimental high-throughput screening (HTS). To discover potent CYP1A1 enzyme inhibitors for cancer chemoprevention, ...