Browsing Leicester School of Pharmacy by Subject "4,6-diaryl-2-pyridones"

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The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells

Lodhi, Sabahat; Ankrett, Dyan N.; Wilsher, Nicola E.; Potter, Gerard A.; Beresford, Kenneth J. M.; Arroo, R. R. J.; Ruparelia, K. C. (Article)

As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones was synthesised in yields of 6-60% from the corresponding chalcones. A number of ...