Browsing Leicester School of Pharmacy by Title
Now showing items 1101-1120 of 1196
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Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K
(Article)The mechanisms by which the dietary compound tangeretin has anticancer effects may include acting as a prodrug, forming an antiproliferative product in cancer cells. Here we show that tangeretin also inhibits cell cycle ... -
Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1/CYP1B1 enzyme induction and CYP1A1/CYP1B1–mediated metabolism to the product 4′ hydroxy tangeretin
(Article)Tangeretin is a polymethoxylated flavone with multifaceted anticancer activity. In the present study, the metabolism and further antiproliferative activity of tangeretin was evaluated in the CYP1 expressing human breast ... -
Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds
(Article)Tissue engineering response may be tailored via controlled, sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional (3D) ice-templated collagen ... -
Targeting microbial biofilms: current and prospective therapeutic strategies
(Article)Biofilm formation is now recognized as a key virulence factor for a wide range of chronic microbial infections. While it has been well known for decades that bacteria and fungi in biofilms become highly tolerant of ... -
Targeting Oxidative Stress Using Tri-Needle Electrospray Engineered Ganoderma Lucidum Polysaccharide-loaded Porous Yolk-Shell Particles
(Article)Chronic lung diseases (e.g. chronic obstructive pulmonary disease and asthma) are associated with oxidative stress and common treatments include various types of inhalation therapies. In this work ganoderma lucidum ... -
Teaching Analytical Chemistry to Pharmacy Students: A Combined, Iterative Approach
(Article)Analytical chemistry has often been a difficult subject to teach in a classroom or lecture-based context. Numerous strategies for overcoming the inherently practical-based difficulties have been suggested, each with differing ... -
A therapeutic update on PARP inhibitors: implications in the treatment of glioma
(Article)Central nervous system (CNS) cancers are among the most aggressive and devastating. Furthermore, because of the lack of neuro-oncologists and neurosurgeons in many parts of the world, the specialized treatment ... -
Thermodynamic Changes Induced by Intermolecular Interaction Between Ibuprofen and Chitosan: Effect on Crystal Habit, Solubility and In Vitro Release Kinetics of Ibuprofen
(Article)Purpose: The direct impact of intermolecular attraction between ibuprofen and chitosan on crystal behaviour, saturated solubility and dissolution efficiency of ibuprofen was investigated in order to expand the drug delivery ... -
Thermoresponsive Gels
(Article)Thermoresponsive gelling materials constructed from natural and synthetic polymers can be used to provide triggered action and therefore customised products such as drug delivery and regenerative medicine types as well as ... -
Through Vial Impedance Spectroscopy
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Through vial impedance spectroscopy (TVIS): A novel approach to process understanding for freeze-drying cycle development
(Book chapter)Through vial impedance spectroscopy (TVIS) provides a new process analytical technology for monitoring a development scale lyophilization process, which exploits the changes in the bulk electrical properties that occur on ...