Browsing Leicester School of Pharmacy by Title
Now showing items 656-675 of 1196
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Kinetic Isotope Effects
(Book chapter)Methods for calculation of kinetic isotope effects and their application to reactions catalysed by enzymes are surveyed, including consideration of cut-off approximations both old and new, empirical bond-order–bond-energy ... -
Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages.
(Article)Phagocytes such as macrophages are capable of detecting and killing pathogenic bacteria by producing reactive oxygen and nitrogen species. Formation of free radicals in macrophages may be regulated by probiotics or by ... -
Laundering of Healthcare Uniforms
(Presentation) -
LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence
(Conference)133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD ... -
LC-HRMS analysis of dried blood spot samples for assessing adherence to cardiovascular medications
(Article)Research suggests that ~60% of patients prescribed cardiovascular drugs do not take their medication correctly. The analysis of dried blood spot samples (DBS) by liquid chromatography-high resolution mass spectrometry ... -
Leather Surfaces: Species Differentiation and Fingermark Visualisation
(Conference)The predominance of latent fingermarks at crime scenes highlights the paramount importance of methodologies for their development and visualisation. However, despite the array of available techniques, prior exposure to ... -
Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling
(Article)The accumulation of lipids in the late endosomes and lysosomes of Niemann–Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used ... -
Liquid chromatography-high resolution mass spectrometry applied to therapeutic drug monitoring using DBS sampling
(Conference)Introduction: Quantitative dried blood spot (DBS) analysis was used to investigate if the accurate mass capability (±2ppm m/z) of high resolution mass spectrometry (HRMS) would provide compound specificity comparable to ... -
Lithium treatment of affective disorders; effects on the cyclic AMP and inositol phospholipid signalling pathways’
(Article)The effects of lithium (Li+) on the adenylyl cyclase and inositol phospholipid receptor signalling pathways were compared directly in noradrenergic and carbachol stimulated rat brain cortical tissue slices. Li+ was a ... -
Long term stability and storage of acrylic derivatised glucose responsive dextran-concanavalin A gels
(Conference)The long term stability of photopolymerised acrylic derivatives of dextran and concanavalin A (con A) and dextran and con A mixtures has been shown at 20 and 37°C by rheological characterisation when stored with and without ... -
Long term stability of glucose responsive dextran methacylate-concanavalin A Methacrylamide gels as part of an implantable artificial pancreas
(Article)A closed loop implantable insulin delivery device which delivers insulin to the peritoneum in an automated fashion linked to changing glucose levels has been developed and previously tested in diabetic rats and pigs. The ...