Browsing Leicester School of Pharmacy by Title

C. difficile spores the gremlin of hospital bed-sheets

CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G(0)/G(1) inhibiting pRB phosphorylation.

Chaudhuri, B.; Aubry, C.; Mahale, S.; Wilson, A. J.; Jenkins, Paul R.; Maréchal, Jean-Didier; Sutcliffe, Michael J. (Article)

Caking behaviour of spray-dried milk powders - using scanning probe microscopy to study nanoscale surface properties

Prime, Dominic; Leaper, Mark C.; Jones, James R.; Richardson, David J.; Rielly, Christopher D.; Stapley, Andrew G. F. (Article)

Atomic force microscopy has been used to study the surface properties of model spray dried powders. Phase imaging, nanoindentation and force modulation microscopy have differentiated between the different surface material ...

Caking behaviour of spray-dried milk powders - using scanning probe microscopy to study nanoscale surface properties

Prime, Dominic; Leaper, Mark C.; Jones, James R.; Richardson, David J.; Rielly, Christopher D.; Stapley, Andrew G. F. (Conference)

Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line

Macho, A.; Blanco-Molina, M.; Spagliardi, P.; Appendino, G.; Bremner, Paul; Heinrich, M.; Fiebich, B. L.; Muñoz, E. (Article)

Can fibre type have a role in the reduction of microorganism survival on healthcare uniforms?

Riley, Kate; Williams, John; Laird, Katie (Conference)

Can H2-receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19 year old female?

Allen, Susan; Dixon, C. J.; Chazot P L (Article)

The anaphylactoid reaction described follows cessation of ranitidine in a 19 year old female with the disease cluster: mast cell activation syndrome, hypermobile Ehlers-Danlos syndrome and postural tachycardia syndrome. ...

Can quantitative dried blood spot analyses be an aid to medicine optimization in cardiovascular diseases?

Bernieh, Dennis; Lawson, Graham; Tanna, Sangeeta (Conference)

Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 2013 [1]. Half of these, costing the NHS £2.3 billion, were wasted because patients do not take their medicines as ...

Cancer and related case studies involving salvestrol and CYP1B1

Schaefer, B. A.; Potter, G. A.; Wood, R.; Burke, M. D. (Article)

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.

Potter, G. A.; Patterson, L. H.; Wanogho, E.; Perry, P. J.; Butler, P. C.; Ijaz, T.; Ruparelia, K. C.; Lamb, J. H.; Farmer, B.; Stanley, L. A.; Burke, M. D. (Article)

Cannabidiol and cannabigerol inhibit spontaneous contractions in the mouse isolated uterus

Brown, James; Teodora, Georgieva; Rajendran, Roshni; Gyeke, Brigitte; Handy, Kirsten; Seifi, Mohsen (Conference)

Background and Purpose: The production of endocannabionoids andthe presence of cannabinoid receptors in mouse uterus havepreviously been reported (Pagano et al., 2017). Furthermore, we havereported how uterine tissue ...

Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies

Lawson, Graham; Mulla, Hussain; Tanna, Sangeeta (Article)

The use of blood spot collection cards was investigated as a means of obtaining small volume samples for the analysis of therapeutic drugs for the purpose of neonatal pharmacokinetic studies. We describe the development ...

Cardiovascular Drug Medication Adherence Assessed by Dried Blood Spot Analysis

Tanna, Sangeeta; Lawson, Graham (Article)

The use of dried blood spot (DBS) collection cards was investigated for the detection of therapeutic drugs used in cardiovascular therapy for assessing medication adherence. A liquid chromatography-high resolution mass ...

Cardiovascular drug medication compliance assessed by dried blood spot sampling techniques

Tanna, Sangeeta; Lawson, Graham (Conference)

Cardiovascular drug monitoring using quantitative LC-HRMS analysis of self-collected micro-volume blood samples

Tanna, Sangeeta; Bernieh, Dennis; Alalaqi, Ahmed; Lawson, Graham (Conference)

Background Evidence suggests that ˃50% of cardiovascular (CVD) disease patients do not adhere to treatment thus impacting on patient health, additional healthcare costs and medicines wastage. DBS microsampling combined ...

Caring for a Child with Learning Disabilities Over a Prolonged Period of Time: An Exploratory Survey on the Experiences and Health of Older Parent Carers Living in Scotland

Cairns, Deborah; Brown, Jayne; Tolson, D.; Darbyshire, Chris (Article)

Background The negative health impacts of prolonged caregiving are widely reported. However, there is a paucity of evidence concerning the impacts of a lifetime of caring on older parents of offspring with learning ...