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    Browsing School of Allied Health Sciences by Subject "ECM"

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      • Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization 

        Randles, Michael J.; Woolf, Adrian S.; Huang, Jennifer L.; Byron, Adam; Humphries, Jonathan D.; Price, Karen L.; Kolatsi-Joannou, Maria; Collinson, Sophie; Denny, Thomas; Knight, David; Mironov, Aleksandr; Starborg, Toby; Korstanje, Ron; Humphries, Martin J.; Long, David A.; Lennon, Rachel (Article)
        Glomerular disease often features altered histologic patterns of extracellular matrix (ECM). Despite this, the potential complexities of the glomerular ECM in both health and disease are poorly understood. To explore whether ...
      • Glomerular Cell Cross-Talk Influences Composition and Assembly of Extracellular Matrix 

        Randles, Michael J.; Byron, Adam; Humphries, Jonathan D.; Mironov, Aleksandr; Hamidi, Hellyeh; Harris, Shelley; Mathieson, Peter W.; Saleem, Moin A.; Satchell, Simon C.; Zent, Roy; Humphries, Martin J.; Lennon, Rachel (Article)
        The glomerular basement membrane (GBM) is a specialized extracellular matrix (ECM) compartment within the glomerulus that contains tissue-restricted isoforms of collagen IV and laminin. It is integral to the capillary ...
      • Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury 

        Randles, Michael J.; Collinson, S.; Mironov, Aleksandr; Koenigshausen, E.; Starborg, T.; Krendel, M.; Sellin, L.; Roberts, I.; Kadler, K.; Miner, J.; Lennon, Rachel (Article)
        Glomeruli are highly sophisticated filters and glomerular disease is the leading cause of kidney failure. Morphological change in glomerular podocytes and the underlying basement membrane are frequently observed in disease, ...

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