• The Differential DNA Hypermethylation Patterns of microRNA-137 and microRNA-342 Locus in Early Colorectal Lesions and Tumours. 

  Kashani, E.; Hadizadeh, M.; Chaleshi, V.; Mirfakhraie, R.; Young, Christopher N. J.; Irani, S.; Asadzadeh Aghdaei, H.; Ashrafian Bonab, M. (Article)

  Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, representing 13% of all cancers. The role of epigenetics in cancer diagnosis and prognosis is well established. MicroRNAs in particular influence ...

• Biosocial Model of Disability 

  Berghs, Maria (Book chapter)

  This chapter began with an introduction to disability and aging as part of the global human condition. It is then argued that a disability perspective is critical to understanding different ways people are aging and those ...

• The social construction of male infertility: A qualitative questionnaire study of men with a male factor infertility diagnosis 

  Hanna, Esmee; Gough, Brendan (Article)

  Although recent research has highlighted the distressing impact of infertility for men, fertility issues are still routinely seen as a ‘women’s issue’ – even when male factor infertility is highlighted. This paper reports ...

• The role of two-pore channels in norepinephrine-induced [Ca2+]i rise in rat aortic smooth muscle cells and aorta contraction. 

  Trufanov, S.K.; Rybakova, E.Y.; Avdonin, P.P.; TSITRINA, A.A.; Goncharov, N.V.; Jenkins, R.O.; Avdonin, P.V. (Article)

  Second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) triggers Ca2+ release via two-pore channels (TPCs) localized in endolysosomal vesicles. The aim of the present work is to evaluate the role of TPCs ...

• Heme binding to human CLOCK affects interactions with the E-box 

  Freeman, S.L.; Kwon, H.; Portolano, N.; Parkin, G.; Venkatraman Girija, U.; Basran, J.; Fielding, A.; Fairall, L.; Svistunenko, D.; Moody, P.; Schwabe, J.; Kyriacou, C.; Raven, E. (Article)

  The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep-wake cycle via 2 basic helix-loop-helix PER-ARNT-SIM ...

• Safety and toxicity evaluation of nutraceuticals in animal models. 

  Goncharov, Nikolay V.; Sobolev, V. E.; Terpilowski, M.A.; Korf, E.A.; Jenkins, R. O. (Book chapter)

  Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables, and fruits. Most of them possess antioxidant or anti-inflammatory properties and are claimed to provide ...

• The impact of infertility on men’s work and finances: Findings from a qualitative questionnaire study 

  Hanna, Esmée; Gough, Brendan (Article)

  The impact of infertility on the emotional, social and relational aspects of men’s lives is now more widely understood. Yet the impact of infertility on men’s working lives and financial status remains largely overlooked. ...

• Hyperhidrosis Priority Setting Partnership: the top 10 research priorities for management and treatment of hyperhidrosis. 

  McDonald, L.; Alexandroff, A.; Radley, K.; Oliver, R.; McPhee, M.; Miller, J.; Hussain, H.; Dunford, Louise (Conference)

  Hyperhidrosis is a common skin condition characterised by abnormal levels of sweating, and affects 1 -3 % of the population. It can cause both physical problems and psychological distress, and significantly affect quality ...

• First detection of Acanthamoeba spp. and Balamuthia mandrillaris in different water ecosystems in Leicestershire (UK). 

  Anjum, U.; Magnet, A.; Lobo-Bedmar, M. C.; Pena-Fernandez, A. (Conference)

  Acanthamoeba spp., Naegleria fowleri and Balamuthia mandrillaris can produce severe brain infections in immunocompetent and immunocompromised individuals. These free‐living amoebae (FLA) have a worldwide distribution. ...

• Lithium, selenium, cobalt and other elements in scalp hair from a group of young Spanish adults 

  Pena-Fernandez, A.; Gonzalez-Munoz, M. J.; Angulo, S.; Lobo-Bedmar, M. C. (Conference)

  Human scalp hair has been suggested as an appropriate tissue to determine body burden of various metals although this raises controversy in the scientific community due to different factors influencing their content in ...

• Incidental finding of sickle cell trait from an everyday diabetes test – should the family practitioner report? retest? refer? 

  Cronin de Chavez, Anna; Dyson, Simon; Babbington, Fiona; Berghs, Maria; Atkin, Karl; Whitelaw, Donald; Miller, Adrian (Article)

  The HbA1c test is increasingly widely used as a diagnostic and screening test for diabetes mellitus type 2 (T2DM) but the presence of haemoglobin variants, such as sickle haemoglobin, can interfere with results in some ...

• Health care professionals' personal and professional views of herbal medicines in the United Kingdom 

  Bhamra, Sukvinder; Slater, Adrian; Howard, Caroline; Heinrich, Michael; Johnson, Mark (Article)

  Healthcare professionals (HCPs) have a pivotal role in optimising patient care and should be familiar with Complementary and Alternative Medicines (CAM). The aim of the study was to explore UK based HCPs personal and ...

• Blended learning for teaching cell culture as part of DMU e-Parasitology. 

  Pena-Fernandez, A.; Evans, M. D.; Hurtado, C.; Acosta, L.; Izquierdo, F.; Magnet, A.; Pena, M. A.; Singh, N.; Fenoy, S.; Bornay, F. J.; del Aguila, C. (Book chapter)

  Emerging and re-emerging human parasites have become a global health threat due to different factors including globalisation, climate and vector ecology changes that have highlighted the necessity of teaching human ...

• Undergraduate training to respond to chemical and biological incidents. 

  Pena-Fernandez, A. (Book chapter)

  Basic training to face chemical and biological incidents is becoming critical for health professionals due to recent global health threats including terrorism. Health professionals need to have appropriate and sufficient ...

• Teaching parasite culture through e-learning incorporating digitised 2D and 3D parasite images. 

  Pena-Fernandez, A.; Llorens, S.; Hurtado, C.; Izquierdo, F.; Pozuelo, M.J.; Fenoy, S.; Young, C.; Evans, M. D.; Ollero, M. D.; del Aguila, C.; Magnet, A. (Conference)

  The teaching of medical parasitology is facing important challenges including the need to reverse the current downward trend in the teaching status of this science reported in developed countries, despite increasing food ...

• Translational blogging: a bidirectional communication between the class and society. 

  Magnet, A.; Fenoy, S.; Hurtado, C.; Ollero, M. D.; Nistal. E.; Angulo, S.; Laguna, R.; Jimenez, P.; Llinares, F.; Robas, M.; Pena-Fernandez, A.; Izquierdo, F.; del Aguila, C.; Pozuelo, M.J. (Conference)

  Higher Education Students (HES) may find the lectures as something far away from their everyday life. Professors feel a big gap between themselves and their pupils. Furthermore, some students can find that subjects are not ...

• Dementia in Conversation: Observations from Triadic Memory Clinic Interactions 

  Elsey, Christopher (Book chapter)

  Dementia is synonymous with a deteriorating 'memory' in those it impacts. However, it is often in conversation that the neuro-degeneration is revealed. This chapter outlines a memory clinic study which sought to explore ...

• Sickle Cell, Work and Employment: A Guide for Employers and Employees on Sickle Cell Disorder (SCD) 

  Berghs, Maria; Morrison, Vanetta; Sokhal, Kalpna; Dyson, Simon (Other)

  Work, Employment and Sickle Cell This guide is based on research examining the experiences of people with sickle cell disorder (SCD) in work and employment in England. There are duties on employers under the 1996 Employment ...

• The Role of Self-Disgust and Emotion Regulation within Recovering from an Eating Disorder: A Mixed Methods, Longitudinal Perspective 

  Bell, Katie; Coulthard, Helen; Wildbur, Diane (Conference)

  1) Background There is a substantial body of literature supporting the view that disordered eating behaviour is broadly characterized by emotion dysregulation but little attention has been paid to the possible mediators ...

• The Angiopoietin ligands and Tie receptors: potential diagnostic biomarkers of vascular disease 

  Bilimoria, Jay; Singh, Harprit (Article)

  The Angiopoietin-1 (Angpt1)/Tie2 signaling pathway is important in regulating vascular function. Angpt1-induced Tie2 activation promotes vascular endothelial cell survival and reduces vascular leakage. Angiopoietin-2 ...

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