School of Allied Health Sciences
Recent Submissions
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Tensin1 expression and function in chronic obstructive pulmonary disease
(Article)Chronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous ... -
Masculinities in the construction industry: A double-edged sword for health and wellbeing?
(Article)Construction remains a male-dominated industry and men in construction suffer high rates of illness and injury compared to other industries. Consideration of men and masculinities may support any attempt to maintain ... -
The Efficacy of Administering Fruit-Derived Polyphenols to Improve Health Biomarkers, Exercise Performance and Related Physiological Responses
(Article)Polyphenols are secondary metabolites involved in a myriad of critical processes in plants. Over recent decades, special attention has been paid to the anti-oxidative role of fruit-derived polyphenols in the human diet, ... -
Evaluation of a novel digital environment for learning medical parasitology.
(Article)Eukaryotic parasites represent a serious human health threat requiring health professionals with parasitology skills to counteract this threat. However, recent surveys highlight an erosion of teaching of parasitology in ... -
Occurrence of ESBL-Producing Escherichia coli ST131, Including the H30-Rx and C1-M27 Subclones, Among Urban Seagulls from the United Kingdom
(Article)Antimicrobial resistance is a public health concern. Understanding any role that urban seagulls may have as a reservoir of resistant bacteria could be important for reducing transmission. This study investigated fecal ... -
Introducing medical parasitology at the University of Makeni, Sierra Leone
(Conference)Capacity building in Sierra Leone (West Africa) is critical to prevent potential future outbreaks similar to the 2013-16 Ebola outbreak that had devastating effects for the country and its poorly developed healthcare ... -
Public Health England’s recovery tools: potential teaching resources?
(Conference)Training to combat chemical and radiation accidents, incidents or attacks is critical for health professionals due to recent events involving these hazards or their use as unconventional weapons, such as the use of the ... -
Learning global public health through international practice: role of #DMUglobal mass trips
(Book chapter)Global public health knowledge is critical to provide healthcare professionals with the necessary skills to respond to outbreaks of infection. To promote infectious disease prevention, detection and response awareness, ... -
Learning clinical biochemistry diagnostic skills through reflection.
(Book chapter)Future health professionals need to acquire analytic and diagnostic skills for prognosis and management of disease. However, future professionals need to be provided with the necessary competences to interpret and process ... -
Biomarkers of Inflammation and Lung recovery in ECMO patients with Persistent Pulmonary Hypertension of the Newborn (PPHN): A feasibility study
(Article)Objectives: Extracorporeal membrane oxygenation is a treatment for Persistent Pulmonary Hypertension of the Newborn with high mortality. Hypothesis: the extracorporeal membrane oxygenation circuit results in inflammatory ... -
Total absence of dystrophin expression exacerbates ectopic myofiber calcification, fibrosis, and alters macrophage infiltration patterns
(Article)Duchenne muscular dystrophy (DMD) causes severe disability and death of young men due to progressive muscle degeneration aggravated by sterile inflammation. DMD is also associated with cognitive and bone-function impairments. ... -
DNA Authentication of St John’s Wort (Hypericum perforatum L.) Commercial Products Targeting the ITS Region
(Article)There is considerable potential for the use of DNA barcoding methods to authenticate raw medicinal plant materials, but their application to testing commercial products has been controversial. A simple PCR test targeting ... -
Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype
(Article)Hutchinson–Gilford progeria syndrome (HGPS) is a rare but devastating genetic disorder that mimics premature aging. Most cases are caused by heterozygous mutations in LMNA, encoding lamin A/C. The allelic disorder, ... -
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton
(Article)Nuclear migration and positioning within cells are critical for many developmental processes and are governed by the cytoskeletal network. Although mechanisms of nuclear-cytoskeletal attachment are unclear, growing evidence ... -
Hutchinson-Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature.
(Article)Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature ageing disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Classical and atypical forms of HGPS have been reported ... -
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
(Article)The nuclear envelope (NE) LINC complex, in mammals comprised of SUN domain and nesprin proteins, provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and ... -
Lamin A-linked progerias: is farnesylation the be all and end all?
(Article)HGPS (Hutchinson-Gilford progeria syndrome) is a severe childhood disorder that appears to mimic an accelerated aging process. The disease is most commonly caused by gene mutations that disrupt the normal post-translational ... -
An observational cohort feasibility study to identify microvesicle and miRNA biomarkers of acute kidney injury following paediatric cardiac surgery
(Article)Objectives: Micro-RNA, small noncoding RNA fragments involved in gene regulation, and microvesicles, membrane-bound particles less than 1 μm known to regulate cellular processes including responses to injury, may serve ... -
Morbid curiosity? Discussion of the disposal of amputated limbs on online question and answer sites
(Article)Amputation is a growing health issue with implications for the corporeal form and sense of bodily identity. Disposal of the removed limb (the amputate) has historically been suggested to impact upon patient adaptation to ...
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