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    The effects of fear conditioning on cerebellar LTP and LTD

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    Zhu-2007- the effect of fear conditioning on cerebellar LTP and LTD.pdf (780.0Kb)
    Date
    2007-09-19
    Author
    Zhu, Lan;
    Scelfo, B.;
    Hartell, N. A.;
    Strata, Piergiorgio;
    Sacchetti, B.
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    Abstract
    Long-term potentiation (LTP) and depression (LTD) at parallel fibre-Purkinje cell synapses have been described in vitro in the cerebellar cortex, but the physiological roles of these two forms of plasticity have not been well defined. Here we show that, in cerebellar slices taken from rats that had undergone fear conditioning, there was a significant occlusion of electrically induced LTP at parallel fibre-Purkinje cell synapses. This effect was long-lasting and related to associative processes, as LTP was not occluded in unpaired animals. Notably, in conditioned animals the LTP-inducing protocol produced LTD in some cells instead of LTP. Conversely, synaptic depression induced by conjunctive stimulation of parallel fibers and climbing fibres was impaired in tissue taken immediately following aversive stimulation in both paired and unpaired subjects. This effect was not, however, long-lasting as the incidence and extent of LTD returned to normal levels 24 h after behavioural testing. These findings suggest that LTP takes part in the mechanisms underlying aversive associative memories in the cerebellum.
    Description
    Citation : Zhu, L. et al. (2007) The effects of fear conditioning on cerebellar LTP and LTD. The European journal of neuroscience, 26 (1), pp. 219-227
    URI
    http://hdl.handle.net/2086/10923
    DOI
    http://dx.doi.org/10.1111/j.1460-9568.2007.05632.x
    ISSN : 0953-816X
    Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
    Peer Reviewed : Yes
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    • School of Allied Health Sciences [1318]

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