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dc.contributor.authorZhu, Lanen
dc.contributor.authorScelfo, B.en
dc.contributor.authorTempia, F.en
dc.contributor.authorSacchetti, B.en
dc.contributor.authorStrata, Piergiorgioen
dc.date.accessioned2015-04-29T14:00:43Z
dc.date.available2015-04-29T14:00:43Z
dc.date.issued2006-09-08
dc.identifier.citationZhu, L. et al. (2006) Membrane excitability and fear conditioning in cerebellar Purkinje cell. Neuroscience, 140 (3), pp. 801-810en
dc.identifier.issn0306-4522
dc.identifier.urihttp://hdl.handle.net/2086/10922
dc.description.abstractIn a previous study it has been demonstrated that fear conditioning is associated with a long-lasting potentiation of parallel fiber to Purkinje cell synaptic transmission in vermal lobules V and VI. Since modifications of intrinsic membrane properties have been suggested to mediate some forms of memory processes, we investigated possible changes of Purkinje cell intrinsic properties following the same learning paradigm and in the same cerebellar region. By means of the patch clamp technique, Purkinje cell passive and active membrane properties were evaluated in slices prepared from rats 10 min or 24 h after fear conditioning and in slices from control naive animals. None of the evaluated parameters (input resistance, inward rectification, maximal firing frequency and the first inter-spike interval, post-burst afterhyperpolarization, action potential threshold and amplitude, action potential afterhyperpolarization) was significantly different between the three studied groups also in those cells where parallel fiber-Purkinje cell synapse was potentiated. Our results show that fear learning does not affect the intrinsic membrane properties involved in Purkinje cell firing. Therefore, at the level of Purkinje cell the plastic change associated with fear conditioning is specifically restricted to synaptic efficacy.en
dc.language.isoenen
dc.publisherNeuroscienceen
dc.subjectmembrane excitabilityen
dc.subjectcerebellumen
dc.subjectPurkinje cellen
dc.subjectfear conditioningen
dc.subjectwhole cell patch clamp recordingen
dc.titleMembrane excitability and fear conditioning in cerebellar Purkinje cellen
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroscience.2006.02.040
dc.peerreviewedYesen
dc.funderMIURen
dc.funderItalian Ministry of Healthen
dc.funderEuropean Communityen
dc.funderRegione Piemonte and Fondazione San Paoloen
dc.projectidResearchen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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