Browsing by Author "Taylor, M. Joan"
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Closed-loop glycaemic control using an implantable artificial pancreas in diabetic domestic pig
Taylor, M. Joan; Gregory, R.; Tomlins, P.; Jacob, D.; Hubble, J.; Sahota, T. S. (Article)The performance of a completely implantable peritoneal artificial pancreas (AP) has been demonstrated in principle in a live diabetic domestic pig. The device consists of a smart glucose-sensitive gel that forms a gateway ... -
Diffusion of fluorescent insulin from an acrylic derivatised dextran-concanavalin A gel in an implantable closed loop insulin delivery device
Jacob, D.; Taylor, M. Joan; Tomlins, P.; Sahota, T. S.; Jaroszkiewicz, E. (Conference)The drug delivery mechanism of fluorescently labelled fluorescein isothiocyanate insulin (FITC-insulin) from a glucose responsive gel held in an implantable closed loop insulin delivery device was found to be diffusion ... -
Long term stability and storage of acrylic derivatised glucose responsive dextran-concanavalin A gels
Sahota, T. S.; Taylor, M. Joan (Conference)The long term stability of photopolymerised acrylic derivatives of dextran and concanavalin A (con A) and dextran and con A mixtures has been shown at 20 and 37°C by rheological characterisation when stored with and without ... -
Long term stability of glucose responsive dextran methacylate-concanavalin A Methacrylamide gels as part of an implantable artificial pancreas
Sahota, T. S.; Tomlins, P.; Taylor, M. Joan (Article)A closed loop implantable insulin delivery device which delivers insulin to the peritoneum in an automated fashion linked to changing glucose levels has been developed and previously tested in diabetic rats and pigs. The ...