Browsing by Author "Bukhari, Nadeem Irfan"
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Correlation between molecular dynamics and physical stability of two milled anhydrous sugars: lactose and sucrose
Smith, Geoff; Hussain, Amjad; Bukhari, Nadeem Irfan; Ermolina, I. (Article)The process of milling often results in amorphization and the physical stability of amorphous phase is linked with its molecular dynamics. This study focuses on a propensity of two disaccharides (lactose and sucrose) to ... -
Development of Paracetamol-Caffeine co-crystals to improve compressional, formulation and in-vivo performance
Ahmad, Z.; Latif, S.; Abbas, N.; Hussain, A.; Arshad, Muhammad Sohail; Bukhari, Nadeem Irfan; Afzal, H.; Riffat, S. (Article)Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared ... -
Quantification of residual crystallinity in ball milled commercially sourced lactose monohydrate by thermo-analytical techniques and terahertz spectroscopy
Smith, Geoff; Hussain, A.; Bukhari, Nadeem Irfan; Ermolina, I. (Article)The quantification of crystallinity is necessary in order to be able to control the milling process. The use of thermal analysis for this assessment presents certain challenges, particularly in the case of crystal hydrates. ... -
Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients
Smith, Geoff; Pedge, Nicholas; Khan, Karrar A; Bukhari, Nadeem Irfan; Hussain, Amjad; Ermolina, I. (Article)The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen by co-milling with different excipients and to establish the underlying mechanism(s) for such enhancement. In the first-part, ...