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    Browsing by Author "Bukhari, Nadeem Irfan"

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      • Correlation between molecular dynamics and physical stability of two milled anhydrous sugars: lactose and sucrose 

        Smith, Geoff; Hussain, Amjad; Bukhari, Nadeem Irfan; Ermolina, I. (Article)
        The process of milling often results in amorphization and the physical stability of amorphous phase is linked with its molecular dynamics. This study focuses on a propensity of two disaccharides (lactose and sucrose) to ...
      • Development of Paracetamol-Caffeine co-crystals to improve compressional, formulation and in-vivo performance 

        Ahmad, Z.; Latif, S.; Abbas, N.; Hussain, A.; Arshad, Muhammad Sohail; Bukhari, Nadeem Irfan; Afzal, H.; Riffat, S. (Article)
        Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared ...
      • Milling and co-milling with various excipients for the improvement of intrinsic dissolution rate of ibuprofen 

        Hussain, Amjad; Ermolina, I.; Bukhari, Nadeem Irfan; Khan, Karrar A.; Smith, Geoff (Conference)
      • Quantification of residual crystallinity in ball milled commercially sourced lactose monohydrate by thermo-analytical techniques and terahertz spectroscopy 

        Smith, Geoff; Hussain, A.; Bukhari, Nadeem Irfan; Ermolina, I. (Article)
        The quantification of crystallinity is necessary in order to be able to control the milling process. The use of thermal analysis for this assessment presents certain challenges, particularly in the case of crystal hydrates. ...
      • Quantification of Residual Crystallinity of ball milled anhydrous lactose using DSC and terahertz spectroscopy 

        Hussain, Amjad; Ermolina, I.; Bukhari, Nadeem Irfan; Smith, Geoff (Conference)
      • Quantification of residual crystallinity of ball-milled, commercially available, anhydrous β-lactose by differential scanning calorimetry and terahertz spectroscopy 

        Smith, Geoff; Ermolina, I.; Hussain, Amjad; Bukhari, Nadeem Irfan (Article)
      • Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients 

        Smith, Geoff; Pedge, Nicholas; Khan, Karrar A; Bukhari, Nadeem Irfan; Hussain, Amjad; Ermolina, I. (Article)
        The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen by co-milling with different excipients and to establish the underlying mechanism(s) for such enhancement. In the first-part, ...
      • Study of Changes in Crystallinity of Ball Milled Mefenamic Acid using Terahertz Pulsed Spectroscopy 

        Hussain, Amjad; Ermolina, I.; Bukhari, Nadeem Irfan; Smith, Geoff (Article)
      • A Study of the Amorphization of Lactose Monohydrate following extended milling times 

        Hussain, Amjad; Ermolina, I.; Bukhari, Nadeem Irfan; Smith, Geoff (Conference)
      • Surface percolation of protons for the creation of crystal defects in lactose monohydrate following short milling times 

        Hussain, Amjad; Ermolina, I.; Bukhari, Nadeem Irfan; Smith, Geoff (Conference)

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