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P2RX7 purinoceptor as a therapeutic target – the second coming?

Young, Christopher N. J.; Gorecki, Dariusz (Article)

The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated ion channels expressed in immune cells, where its activation triggers the inflammatory cascade. Therefore, P2RX7 has been long investigated ...

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

Sinadinos, Anthony; Young, Christopher N. J.; Al-Khalidi, Rasha; Teti, Anna; Kalinski, Pawel; Mohamad, Shafini; Floriot, Léonore; Henry, Tiphaine; Tozzi, Gianluca; Jiang, Taiwen; Wurtz, Olivier; Lefebvre, Alexis; Shugay, Mikhail; Tong, Jie; Vaudry, David; Arkle, Stephen; doRego, Jean-Claude; Górecki, Dariusz (Article)

Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile ...

P2X receptor signalling in skeletal muscle health and disease

Young, Christopher N. J.; Sinadinos, Anthony; Gorecki, Dariusz (Article)

Skeletal muscle (SM) is a heterogeneous and dynamic tissue that changes significantly in its form and function in response to external and internal stimuli and throughout life, from development right through to aging. ...

P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: Relationship to pathology and potential target for treatment.

Young, Christopher N. J.; Brutkowski, W.; Arkle, Stephen; Lochmuller, H.; Zablocki, K.; Gorecki, Dariusz; Lien, C-F. (Article)

Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca2 homeostasis and cell signalling. Here, in the mdx mouse model ...

P2Y receptor regulation of cultured rat cerebral cortical cells: calcium responses and mRNA expression in neurons and glia.

Webb, T. E.; Bennett, G. C.; Smith, J. A. M.; Ford, A. P. W. D.; Emmett, Caroline J.; Boarder, M. R. (Article)

P2Y Receptors: Structure and Function

Boarder, M. R.; Webb, T. E. (Book chapter)

Pack carburisation of commercially pure titanium with limited oxygen diffusion for improved tribological properties

Bailey, Richard; Sun, Yong (Article)

In the present work a new pack carburising surface treatment method has been developed, whereby oxygen diffusion and carburization of commercially pure titanium was undertaken. Pack carburization was carried out with a ...

Package holidays to Spain in the 1950s and 1960s

Barton, Susan (Article)

Pageantry and populism, democratization and dissent: the forgotten 1970s

Monk, Claire (Book chapter)

PageRank in Malware Categorization

Yerima, Suleiman; Sezer, Sakir; Kang, B.; McLaughlin, K. (Conference)

In this paper, we propose a malware categorization method that models malware behavior in terms of instructions using PageRank. PageRank computes ranks of web pages based on structural information and can also compute ranks ...

PAID-11: a brief measure of diabetes distress validated in adults with type 1 diabetes

Stanulewicz, Natalia; Mansell, P.; Cooke, D.; Hopkins, D.; Speight, J.; Blake, H. (Article)

Objective: The Problem Areas In Diabetes (PAID) questionnaire is widely used to assess emotional distress related to living with diabetes, although it is lengthy for routine clinical use. Our aim was to determine whether ...

Pain Catastrophizing and Fear of Pain predict the Experience of Pain in Body Parts not targeted by a Delayed-Onset Muscle Soreness procedure

Niederstrasser, Nils Georg; Meulders, A.; Meulders, M.; Slepian, P.; Vlaeyen, J.; Sullivan, M. J. L. (Article)

The present study examined whether pain catastrophizing and pain-related fear predict the experience of pain in body regions that are not targeted by an experimental muscle injury protocol. A delayed-onset muscle soreness ...