School of Allied Health Sciences
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Item Open Access The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium(MDPI, 0024-03-11) Janchivlamdan, Dolgormaa; Shivkumar, Maitreyi; Singh, HarpritSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause potentially life-threatening coronavirus disease (COVID-19). COVID-19 is a multisystem disease and is associated with significant respiratory distress, systemic hyperinflammation, vasculitis, and multi-organ failure. SARS-CoV-2 causes the deterioration of numerous systems, with increasing evidence implying that COVID-19 affects the endothelium and vascular function. The endothelium is important for preserving vascular tone and homeostasis. The overactivation and dysfunction of endothelial cells are significant outcomes of severity in patients with COVID-19. The Angiopoietin 1/Tie 2 pathway plays an important role in endothelium quiescence and vessel stability. The disruption of Angiopoietin/Tie balance affects the vessel contact barrier and leads to vessel leakage, and this in turn causes endothelial dysfunction. Although vascular instability through SARS-CoV-2 is associated with endothelial dysfunction, it is still not understood if the virus affects the Angiopoietin/Tie axis directly or via other mechanisms such as cytokine storm and/or immune response associated with the infection. This review provides an overview of the impact SARS-CoV-2 has on endothelial function and more specifically on the Angiopoietin/Tie pathway.Item Metadata only Subcellular Fractionation of Candida stellatoidea after Growth with Glucose or n-Hexadecane(SOC GENERAL MICROBIOLOGY, 1983-02) Jenkins, R. O.; Cartledge, T. G.; Lloyd, D.Item Metadata only Adaptive changes in yeast membranes: catabolite repression and oxygen.(PORTLAND PRESS, 1984) Jenkins, R. O.; Cartledge, T. G.; Lloyd, D.Item Metadata only ICI Symposium on Aromatic Bioconversation(1984-07) Jenkins, R. O.Item Metadata only Respiratory adaptation of anaerobically grown Saccharomyces uvarum: Changes in distribution of enzymes(SOC GENERAL MICROBIOLOGY, 1984-11) Jenkins, R. O.; Cartledge, T. G.; Lloyd, D.Item Metadata only Subcellular Fractionation of Candida boidinii after Growth on Glucose or Methanol.(SOC GENERAL MICROBIOLOGY, 1985) Jenkins, R. O.; Cartledge, T. G.; Lloyd, D.Item Metadata only The use of indole as a spectrophotometric assay substrate for toluene dioxygenase.(ELSEVIER SCIENCE BV, 1985) Jenkins, R. O.; Dalton, H.Item Metadata only Changes in the survival curve shape of E. coli cells following irradiation in the presence of uncouplers of oxidative phosphorylation.(Taylor and Francis, 1985) Anderson, R. F.; Patel, K. B.; Evans, M. D.Item Metadata only ICI Conference on Aromatic Bioconversations(1985-03) Jenkins, R. O.Item Metadata only A Fourier transform infrared investigation of the structural differences between ribonuclease A and ribonuclease S.(1986) Haris, P. I. (Parvez I.); Lee, D.C.; Chapman, D.Item Metadata only Professionals, mentally handicapped children and confidential files(Carfax, 1986) Dyson, SimonThe professional files kept on ESN (S) children contain self-contradictory justifications for school placements; damaging social stereotyping; moral evaluation of parents; professional procedures involving circularity of thought, and attempts by professionals to protect themselves from the type of abuse to which they subject the children and their parents. On the basis that confidentiality offends both quality of information and basic human rights, the abolition of such confidential or secret files is demanded.Item Metadata only Fourier transform infrared spectroscopic studies of gastric H+/K+-ATPase.(1986) Haris, P. I. (Parvez I.); Mitchell, R.C.; Fallowfield, C.; Keeling, D.J.; Chapman, D.Item Metadata only Evidence for more than one form of toluene cis-glycol dehydrogenase from Pseudomonas putida(1986-04) Jenkins, R. O.; Stephens, G. M.; Dalton, H.Item Metadata only Production of aromatic cis-glycols using mutant micro-organisms(1986-04) Jenkins, R. O.; Stephens, G. M.; Dalton, H.Item Metadata only The revertants of Pseudomonas putida NGI(1986-07) Jenkins, R. O.Item Metadata only Changes in proteinase activities and subcellular distribution during inactivation of alcohol oxidase in Candida boidinii(PORTLAND PRESS, 1986-08) Jenkins, R. O.; Hill, D. L.; Cartledge, T. G.; Lloyd, D.Item Metadata only Conference, Stability of oxygenase-catalysed biotransformations(1986-09) Stephens, G. M.; Jenkins, R. O.; Porter, D.; Dalton, H.Item Metadata only Lab Mate: a graph plotting package for the BBC microcomputer.(1987) Jenkins, R. O.Item Metadata only Production of toluene cis-glycol by Pseudomonas putida in glucose fed-batch culture.(JOHN WILEY & SONS INC, 1987) Jenkins, R. O.; Stephens, G. M.; Dalton, H.Item Metadata only Fourier-Transform Infra-Red Studies of Cytochrome c Oxidase(1987) Wrigglesworth, J. M.; Haris, P. I. (Parvez I.); Grahn, M.F; Chapman, D.Kinetic studies using isolated cytochrome oxidase have shown that two distinct functional forms of the enzyme exist (1). The fully oxidised (resting) enzyme, as isolated, oxidises cytochrome c relatively slowly and binds cyanide with low affinity. However, if the enzyme is fully reduced prior to reaction with oxygen for at least one catalytic cycle, then a “pulsed” form is produced in which both cytochrome c oxidation and cyanide binding is markedly increased (1, 2). The “pulsed” form of the enzyme is unstable and, depending on the conditions of incubation, decays back to the resting form within minutes. If the transition between resting and pulsed enzyme were to involve any changes in the conformation of the protein then it might be expected that these changes would also be seen between the oxidised (resting) enzyme and the fully reduced enzyme, since full reduction followed by re-oxidation is one method for producing the pulsed enzyme.