Repository logo
  • Log In
Repository logo
  • Communities & Collections
  • All of DORA
  • Log In
  1. Home
  2. Browse by Author

Browsing by Author "Woodruff, M.A."

Now showing 1 - 1 of 1
Results Per Page
Sort Options
  • Loading...
    Thumbnail Image
    ItemOpen Access
    Microparticles for sustained growth factor delivery in the regeneration of critically-sized segmental tibial bone defects
    (MDPI, 2016-03-31) Kirby, G.T.S.; White, L.J.; Steck, R.; Berner, A.; Bogoevski, K.; Qutachi, Omar; Jones, B.; Saifzadeh, S.; Hutmacher, D.W.; Shakesheff, K.M.; Woodruff, M.A.
    This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles.
Quick Links
  • De Montfort University Home
  • Library Learning Services
  • DMU Figshare (DMU's Data Repository)
Useful Links
  • Submission Guide
  • DMU Open Access Libguide
  • Take Down Policy
  • Connect with DORA

Kimberlin Library

De Montfort University
The Gateway
Leicester, LE1 9BH
0116 257 7042
justask@dmu.ac.uk

DSpace software copyright © 2002-2025 LYRASIS

  • Cookie settings
  • Privacy policy
  • End User Agreement
  • Send Feedback