Browsing by Author "Rembovskiy, V."

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    Russian VX
    (Elsevier Inc./Academic Press, 2020-04-27) Rembovskiy, V.; Savelieva, A.; Radilov, A.; Samchenko, N.; Karakashev, G.; Leninskiy, M.; Koryagina, N.; Kuznetsov, S.; Mindukshev, I.; Khlebnikova, N.; Jenkins, R. O.; Goncharov, N. V.
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    Russian VX
    (Elsevier, 2015) Rembovskiy, V.; Radilov, Andrey S.; Savelieva, E. I.; Kuznetsov, S.; Mindukshev, I. V.; Prokofieva, Daria S.; Krivorotova, N.; Khlebnikova, N. S.; Jenkins, R. O.; Goncharov, Nikolay V.
    Presented in this chapter are data on the principal hydrolysis products of Russian VX (RVX) with excess and equimolar quantity of water, as well as a generalized list of compounds extracted from samples of construction materials of a former RVX production facility. Toxicokinetic experiments have been conducted to determine decrease of O-alkyl methylphosphonates in blood plasma of rats after i.m. administration of RVX. MS/MS peptide spectra obtained with commercially available human albumin incubated with RVX revealed covalent binding of RVX to Tyr 411 and Tyr150. A new covalent adduct of N,N-diethyl-2-aminoethanthiol (a RVX hydrolysis product) with blood plasma proteins has been detected by HPLC–MS/MS, and this can be another marker of exposure to RVX. New data on effects developed under chronic exposure of rats to RVX are presented: these are kinetic parameters of blood platelet aggregation and electrophysiology of Nervus tibialis. According to these data, morphofunctional changes at the level of the microcirculatory bed may prove to be a significant factor in the etiology of delayed effects.
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    Russian VX: monitoring and toxicity
    (Elsevier, 2009) Radilov, Andrey S.; Rembovskiy, V.; Rybalchenko, I.; Savelieva, E. I.; Podolskaya, E.; Babakov, Vladimir N.; Ermolaeva, E. E.; Dulov, S.; Kuznetsov, S.; Mindukshev, I. V.; Shpak, A.; Krasnov, I.; Khlebnikova, N. S.; Jenkins, R. O.; Goncharov, Nikolay V.