Browsing by Author "McClellan, J."

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    The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients
    (MDPI, 2018-02-13) Asadzadeh-Aghdaei, H.; Zali, M. R.; Bonab, Maziar Ashrafian; McClellan, J.; Young, Christopher N. J.; Anaraki, F.; Nazemalhosseini-Mojarad, E; Larki, P.; Gharib, E.; Peyravian, N.
    A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes, information which is also important in assessing any possibilities of lymph node resection so as to improve survival. In this review we perform a wide range assessment of literature relating to recent developments in gene expression profiling (GEP) of the primary tumour, to determine their utility in assessing node status. A set of characteristic genes seems to be involved in the prediction of lymph node metastasis (LNM) in colorectal patients. Hence, GEP is applicable in personalised/individualised/tailored therapies and provides insights into developing novel therapeutic targets. Not only is GEP useful in prediction of LNM, but also allows classification based on differences such as sample size, target gene expression and examination method.
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    GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients
    (2018-02-22) Hadizadeh, M.; Ardebili, S.M.M.; Salehi, M.; Young, Christopher N. J.; Mokarian, F.; McClellan, J.; Xu, Q.; Kazemi, M.; Moazam, E.; Mahaki, B.; Bonab, Maziar Ashrafian
    Lymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function which leads to obstruction of the lymphatic system. Secondary Lymphedema is a progressive and incurable condition, most often manifesting after surgery for breast cancer. Although its causation appears complex, various lines of evidence indicate genetic predisposition may play a role. Previous studies show that mutations in Connexin 47 are associated with secondary lymphedema. We have tested the hypothesis that connexin 37 gene mutations in humans are associated with secondary lymphedema following breast cancer surgery. 2211 breast cancer patients were screened and tested for reference single nucleotide polymorphisms of the GJA4 gene. The results presented in this paper indicate that two SNPs in the 3’ UTR of the GJA4 gene are associated with increased risk of secondary lymphedema in patients undergoing breast cancer treatment. Our results provide evidence of a novel genetic biomarker for assessing predisposition to secondary lymphedema in human breast cancer patients. Testing for the condition-associated alleles described here could assist and inform treatment and post-operative care plans of breast cancer patients, with potentially positive outcomes for the management of disease progression.