Browsing by Author "Manshian, Bella"

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    Implantable Electrochemical Biosensors – A Perspective
    (Pan Stanford Publishing, 2012-11-21) Govindarajan, S.; Manshian, Bella
    Intensive research in micro/nano biosensors has resulted in a variety of sensors for monitoring different analytes for applications ranging from environmental pollutants to neuroscience. Although several biomedical sensors have been tested on animals, they are yet to reach the stage of continuous and reliable patient monitoring. For onsite impact, it is therefore imperative to transfer the sensor technology developed in the laboratories to a clinical setting to facilitate medical diagnostics in order to aid and guide treatment regimes. This chapter will elaborate on electrochemical micro/nano biosensors and wireless sensors utilized for implantation within the human body to measure the concentration of analytes, biomolecules, drugs or physical parameters such as temperature, pressure and so on. Sensor parameters such as sensitivity, selectivity, biofouling, biocompatibility, sterility and toxicity will be addressed. To address some of the previously mentioned issues, dialysis electrodes and ex vivo monitoring through blood sampling have also been considered. In addition, hurdles that need to be overcome to produce implantable micro/nano biosensors capable of continuous monitoring of analytes from a human subject will be discussed.
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    Quantum Dot induced Cellular Perturbations Involving Varying Toxicity Pathways.
    (Royal Society of Chemistry, 2015-01-06) Al Ali, A.; Singh, Neenu; Manshian, Bella; Wilkinson, Tom; Jenkins, Gareth J. S.; Doak, Shareen H.
    The unique optical and electronic properties of quantum dots (QD) have led to rapid progress in their development and application, particularly in innovative therapeutic and diagnostic products. Along with the great pace at which QD are being developed, research is being focussed on fabricating less toxic QD with novel surface functionalities. The present study was therefore focused on assessing the impact of varying QD surface chemistry on cellular uptake and a range of indicators for cell perturbation following exposure. The study demonstrated that despite a low intrinsic cytotoxicity of three QD with different surface functional groups, they were all capable of inducing an acute inflammatory response and alterations in transcriptional gene activity, without affecting cell cycle regulation. Further, this investigation demonstrated that although the QD were capable of inducing an inflammatory and oxidative stress response, there was clearly variation in the degree of molecular change according to surface chemistry, which correlated with the degree of cellular uptake. These findings therefore highlight the potential for chronic inflammatory responses following exposure to QD, but in addition, they also demonstrate the importance of studying a wide range of toxicity pathways to generate a comprehensive picture of biological response to nanomaterials.