Browsing by Author "Huang, J."

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    Automating business intelligence recovery from a web-based system.
    (2010) Kang, Jian; Li, J.; Huang, J.; Tian, Y.; Yang, Hongji
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    Development of Random and Ordered Composite Fiber Hybrid Technologies for Controlled Release Functions
    (Elsevier, 2018-03-06) Wang, Baolin; Ahmad, Z.; Huang, J.; Li, Jing-Song; Chang, Ming-Wei
    Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCL) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate anti-bacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.
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     The role of electrosprayed nanoapatites in guiding osteoblast behaviour
    (2008) Thian, E.; Ahmad, Z.; Huang, J.; Edirisinghe, M.; Jayasinghe, S.; Ireland, D.; Brooks, R.; Rushton, N.; Bonfield, W.; Best, S.
    Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.
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    Supporting context - Aware service evolution with a process management requirements model .
    (IEEE, 2011) Huang, J.; Yang, Hongji; Xu, L.; Xu, B.; Zhang, H.