Browsing by Author "Heinrich, M."
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Item Metadata only Antifungal constituents of Melicope borbonica(John Wiley and Sons, 2004) Simonsen, H. T.; Adsersen, A.; Bremner, Paul; Heinrich, M.; Smitt, U. W.; Jaroszewski, J. W.Item Metadata only Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators.(Elsevier, 2009) Bremner, Paul; Rivera, D.; Calzado, M. A.; Obon, C.; Inocencio, C.; Beckwith, C.; Fiebich, B. L.; Muñoz, E.; Heinrich, M.Item Metadata only Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx(Georg Thieme Verlag, 2003) Tang, S.; Bremner, Paul; Kortenkamp, A.; Schlage, C.; Gray, A. I.; Gibbons, S.; Heinrich, M.Item Metadata only Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line(Elsevier, 2004) Macho, A.; Blanco-Molina, M.; Spagliardi, P.; Appendino, G.; Bremner, Paul; Heinrich, M.; Fiebich, B. L.; Muñoz, E.Item Metadata only Comparison of different Rhodiola species using NMR-metabolomics, HPTLC and DNA barcoding techniques(2016-07) Booker, Anthony; Zhai, Lixiang; Gkouva, C.; Li, Shuyuan; Frommenwiler, Debora; Reich, Eike; Howard, Caroline; Sgamma, Tiziana; Williams, Sarah; Slater, A.; Heinrich, M.The fast developing international trade of products based on local and traditional knowledge and their associated value chains have become an important aspect of the ethnopharmacological debate. The structure and diversity of value chains and their impact on the phytochemical composition of herbal medicinal products (HMPs) has been overlooked in quality issues in transnational trade. Medicinal Rhodiola species, including R. rosea L. and R. crenulata (Hook.f. & Thomson) H.Ohba, abbreviate genus have been widely used as traditional herbal medicines with numerous claims for their therapeutic effects [1]. Faced with resource depletion and environment destruction, R. rosea and R. crenulata are becoming endangered, making them more economically valuable to collectors and middlemen, and also increasing the risk of adulteration and low quality. This study compares the phytochemical differences among Rhodiola raw materials available on the market and provides a practical method for Rhodiola authentication. Nuclear magnetic resonance (NMR) spectroscopy coupled with multivariate analysis software and high performance thin layer chromatography (HPTLC) techniques were used to analyse the phytochemical differences between five Rhodiola species. We compared the phytochemical composition of collected Rhodiola samples to authenticated samples. Rosavin and rosarin were mainly present in R. rosea whereas an unknown compound was only present in R. crenulata. 30% of the Rhodiola samples purchased from the Chinese market were adulterated by other Rhodiola spp. 7% of the raw-material samples were not labelled properly and the species information was not clearly illustrated. Both 1H-NMR and HPTLC methods provided an integrated analysis of the phytochemical differences between the species studied. This study provided an identification method for R. rosea and R. crenulata and provided further analytical data that could form the basis for the identification of other species. The integrated identification approach combining these two analytical platforms offers an innovative and practical way of assessing the chemical variability along the value chains of medicinal plants.Item Metadata only Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin(American Chemical Society, 2004) Appendino, G.; Bianchi, F.; Bader, A.; Campagnuolo, C.; Fattorusso, E.; Taglialatela-Scafati, O.; Blanco-Molina, M.; Macho, A.; Fiebich, B. L.; Bremner, Paul; Heinrich, M.; Ballero, M.; Muñoz, E.Item Metadata only Cytotoxic activity of a podophyllotoxin-like lignan from Linum tauricum Willd(Veda, 2005) Vasilev, N.; Momekov, G.; Zaharieva, M.; Konstantinov, S.; Bremner, Paul; Heinrich, M.; Ionkova, I.Item Metadata only Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones(Elsevier, 2003) Hilmi, F.; Gertsch, J.; Bremner, Paul; Valovic, S; Heinrich, M.; Sticher, O.; Heilmann, J.Item Metadata only Ethnobotany and ethnopharmacy - Their role for anti-cancer drug development(Bentham Science Publisher Ltd., 2006) Heinrich, M.; Bremner, PaulItem Metadata only Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT(Georg Thieme Verlag, 2004-11) Marquez, N.; Sancho, R.; Ballero, M.; Bremner, Paul; Appendino, G.; Fiebich, B. L.; Heinrich, M.; Muñoz, E.Item Metadata only Natural products as targeted modulators of the nuclear factor-kappa B pathway(Royal Pharmecuitical Society, 2002) Bremner, Paul; Heinrich, M.Item Metadata only NF-kappa B modulators from Valeriana officinalis(John Wiley and Sons, 2006-10) Jacobo-Herrera, N. J.; Vartiainen, Nina; Bremner, Paul; Gibbons, S.; Koistinaho, J.; Heinrich, M.Item Metadata only Phenylpropanoids NF-KB inhibitors from Bupleurum fruticosum.(Georg Thieme Verlag, 2004-09-01) Bremner, Paul; Birkmayer, H.; Fiebich, B. L.; Tang, S.; Muñoz, E.; Marquez, N.; Rivera, D.; Heinrich, M.Item Metadata only Physalins from Witheringia solanacea as modulators off the NF-kappa B cascade(American Chemical Society, 2006) Jacobo-Herrera, N. J.; Bremner, Paul; Marquez, N.; Gupta, M. P.; Gibbons, S.; Muñoz, E.; Heinrich, M.Item Open Access The Use of Traditional Herbal Medicines Amongst South Asian Diasporic Communities in the UK(Wiley, 2017-09-14) Bhamra, Sukvinder; Slater, A.; Howard, Caroline; Johnson, Mark, 1948 Mar. 16-; Heinrich, M.Migrant South Asian communities in the UK have brought with them their own traditional forms of medicine, yet little is known about their current use of herbal medicines (HMs) in the UK. The aim of the study was to explore the origins, use and transmission of knowledge of traditional HMs used by diasporic South Asian communities in the UK. A researcher-administered questionnaire was used for data collection (n = 192). An opportunity sampling technique was used to recruit participants across several locations in Birmingham and Leicester. Two thirds of participants (n = 126) stated they used HMs to maintain their health and to treat various health conditions such as digestive problems, skin conditions and diabetes. Almost 2000 actively used HMs were documented including 123 plant species that were identified. Participants imported HMs from abroad as well as sourcing them locally and even growing some of their own plants. Up to 82% (n = 87) of participants who took prescription medicines did not tell their healthcare professionals about any HMs they consumed; this raises concerns about people’s knowledge of herb–drug interactions, compliance and effect on prescribed medicine regimens. Similar studies to explore the use of HMs by other ethnic groups are imperative to help optimise pharmaceutical care of patients.