Browsing by Author "Chen, Y.-J."

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    Cerebro-Cerebellar Pathways for Verbal Working Memory
    (Frontiers Media, 2019-01-08) Sobczak-Edmans, M.; Lo, Y.-C.; Hsu, Y.-C.; Chen, Y.-J.; Kwok, F.Y.; Chuang, K. H.; Tseng, W.-Y.; Chen, S. H. A.
    The current study examined the structural and functional connectivity of the cerebrocerebellar network of verbal working memory as proposed by Chen and Desmond (2005a). Diffusion spectrum imaging was employed to establish structural connectivity between cerebro-cerebellar regions co-activated during a verbal working memory task. The inferior frontal gyrus, inferior parietal lobule, pons, thalamus, superior cerebellum and inferior cerebellum were used as regions of interest to reconstruct and segment the contralateral white matter cerebro-cerebellar circuitry. The segmented pathways were examined further to establish the relationship between structural and effective connectivity as well as the relationship between structural connectivity and verbal working memory performance. No direct relationship between structural and effective connectivity was found but the results demonstrated that structural connectivity is indirectly related to effective connectivity as DCM models that resembled more closely with underlying white matter pathways had a higher degree of model inference confidence. Additionally, it was demonstrated that the structural connectivity of the ponto-cerebellar tract was associated with individual differences in response time for verbal working memory. The findings of the study contribute to further our understanding of the relationship between structural and functional connectivity and the impact of variability in verbal working memory performance.
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    Contralateral Cerebro-Cerebellar White Matter Pathways for Verbal Working Memory: A Combined Diffusion Spectrum Imaging and fMRI Study
    (24th ISMRM Conference, 2016-05) Sobczak-Edmans, M.; Lo, Y.-C.; Hsu, Y.-C.; Chen, Y.-J.; Kwok, F.Y.; Chuang, K. H.; Tseng, W.-Y.; Chen, S. H. A.
    Diffusion spectrum imaging was employed to establish structural connectivity between cerebro-cerebellar regions co-activated during verbal working memory. IFG, IPL, pons, thalamus, superior cerebellum and inferior cerebellum were used as seed points to reconstruct the white matter cerebro-cerebellar circuitry. The reconstructed pathways were examined further to establish the relationship between structural and effective connectivity as well as the relationship between structural connectivity and verbal working memory performance. It was found that structural connectivity is indirectly related to effective connectivity but does not predict it. Additionally, it was demonstrated that the integrity of the ponto-cerebellar tract is an important factor in explaining individual differences in verbal working memory. The findings of the study furthered our understanding of the relationship between structural and functional connectivity and provided insight to the variability in verbal working memory performance.